Ameliorative effect of SA4503, a novel cognitive enhancer, on the basal forebrain lesion-induced impairment of the spatial learning performance in rats

Pharmacology, Biochemistry, and Behavior
T SendaS Mita

Abstract

We investigated the effect of successive administrations of SA4503 (1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride), a novel cognitive enhancer with high affinity and selectivity for the sigma1 receptor subtype, on the cortical cholinergic dysfunction-induced impairment of the spatial learning performance in the Morris water maze (MWM) task in rats. The impairment of the spatial learning performance was produced by the ibotenic acid-induced lesion of the basal forebrain (BF) area in rats. Escape latencies to find the platform during the training trials of the MWM task were significantly prolonged in the BF-lesioned rats compared with the sham-operated rats. Daily treatment with SA4503 (0.1-0.5 mg/kg, P.O./day) for 13 days ameliorated this learning deficit. In the probe trial, BF-lesioned rats reduced the number of times each rat crossed the former platform location during the training trials (goal area) in comparison with sham-operated rats. Successive administrations of SA4503 (0.25 mg/kg, P.O./day) also significantly increased the BF lesion-induced reduction of the number of times each rat crossed the goal area. These results suggest that the successive administrations of SA4503 attenuate the impairme...Continue Reading

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Citations

Nov 5, 1998·Pharmacology, Biochemistry, and Behavior·T KobayashiS Mita
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M NakazawaS Mita
Apr 26, 2007·Dementia and Geriatric Cognitive Disorders·Aleksandra MaruszakMaria Barcikowska
Jan 12, 2010·Behavioural Brain Research·Aren van WaardeRudi A Dierckx
Feb 5, 2014·British Journal of Pharmacology·L ZvejnieceM Dambrova
Oct 1, 2005·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter J SnyderPaul Maruff
Dec 3, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nisha K RamakrishnanAren van Waarde
Oct 3, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nisha K RamakrishnanAren van Waarde
Aug 3, 2012·Journal of Medicinal Chemistry·Michelle L JamesFrederick T Chin

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