Abstract
We investigated the effect of successive administrations of SA4503 (1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride), a novel cognitive enhancer with high affinity and selectivity for the sigma1 receptor subtype, on the cortical cholinergic dysfunction-induced impairment of the spatial learning performance in the Morris water maze (MWM) task in rats. The impairment of the spatial learning performance was produced by the ibotenic acid-induced lesion of the basal forebrain (BF) area in rats. Escape latencies to find the platform during the training trials of the MWM task were significantly prolonged in the BF-lesioned rats compared with the sham-operated rats. Daily treatment with SA4503 (0.1-0.5 mg/kg, P.O./day) for 13 days ameliorated this learning deficit. In the probe trial, BF-lesioned rats reduced the number of times each rat crossed the former platform location during the training trials (goal area) in comparison with sham-operated rats. Successive administrations of SA4503 (0.25 mg/kg, P.O./day) also significantly increased the BF lesion-induced reduction of the number of times each rat crossed the goal area. These results suggest that the successive administrations of SA4503 attenuate the impairme...Continue Reading
References
Mar 20, 1992·Brain Research·K MatsunoS Mita
Aug 6, 1991·European Journal of Pharmacology·J L JunienX Pascaud
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·V J DeNobleR M Scribner
Jun 1, 1990·Experimental Neurology·P F Kwo-On-YuenL J Thal
Nov 13, 1986·The New England Journal of Medicine·W K SummersA Kling
Jan 1, 1985·Psychopharmacology·C G Gottfries
Jan 1, 1988·Psychopharmacology·R J Mandel, L J Thal
Sep 1, 1986·Neuroscience·D Collerton
Dec 1, 1986·Neuroscience·P EtienneR Quirion
Mar 1, 1986·Behavioral and Neural Biology·J F Flood, A Cherkin
Jul 1, 1985·Pharmacology, Biochemistry, and Behavior·R T BartusS K Fisher
Jul 1, 1983·Journal of Neurochemistry·D M BowenA N Davison
Mar 11, 1983·Science·J T CoyleM R DeLong
Jun 1, 1983·Pharmacology, Biochemistry, and Behavior·C FlickerR T Bartus
Jul 30, 1982·Science·R T BartusA S Lippa
Nov 24, 1994·European Journal of Pharmacology·F WanibuchiS Usuda
Aug 11, 1994·European Journal of Pharmacology·K MatsunoS Mita
Nov 30, 1993·European Journal of Pharmacology·S Yoshida, N Suzuki
Jun 3, 1996·European Journal of Pharmacology·M ShinodaK Toide
Jun 13, 1996·European Journal of Pharmacology·K MatsunoS Mita
Nov 7, 1996·European Journal of Pharmacology·T SendaS Mita
Feb 1, 1997·Physiology & Behavior·T SendaS Mita
Feb 1, 1997·Behavioural Brain Research·K MatsunoS Mita
Citations
Jul 10, 1999·Synapse·Y MinabeC R Ashby
Feb 26, 2004·Neuroscience·J LeeS Y Chai
Nov 5, 1998·Pharmacology, Biochemistry, and Behavior·T KobayashiS Mita
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·M NakazawaS Mita
Dec 18, 2001·Brain Research. Brain Research Reviews·T MauriceP Romieu
Apr 26, 2007·Dementia and Geriatric Cognitive Disorders·Aleksandra MaruszakMaria Barcikowska
Jan 23, 2016·Progress in Neurobiology·Lhassane IsmailiJosé Marco-Contelles
Jan 12, 2010·Behavioural Brain Research·Aren van WaardeRudi A Dierckx
Jun 19, 2004·British Journal of Pharmacology·Johann MeunierTangui Maurice
Feb 28, 2009·Journal of Neurochemistry·Vuokko AntoniniGiampiero Leanza
Feb 5, 2014·British Journal of Pharmacology·L ZvejnieceM Dambrova
Oct 1, 2005·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter J SnyderPaul Maruff
Dec 11, 1999·Japanese Journal of Pharmacology·T MauriceT Nabeshima
Dec 3, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nisha K RamakrishnanAren van Waarde
Oct 3, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nisha K RamakrishnanAren van Waarde
Feb 14, 2006·Journal of Pharmacological Sciences·François P Monnet, Tangui Maurice
Aug 3, 2012·Journal of Medicinal Chemistry·Michelle L JamesFrederick T Chin
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Katsura TottoriC Anthony Altar
Oct 20, 2020·Expert Opinion on Drug Discovery·Tangui Maurice
Dec 1, 2001·Journal of Medicinal Chemistry·Y HuangR H Mach