Ameliorative effects of Achillea millefolium inflorescences alcoholic extract against nicotine-induced reproductive failure in rat

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
M Hallaj SalahipourHassan Malekinejad

Abstract

Nicotine (Nic) is a major risk factor in the development of functional disorders of male reproductive system. Achillea millefolium; is highly regarded for medicinal activities, due to its antioxidant and anti-inflammatory properties. This study was carried out to evaluate whether Achillea millefolium (Achm) inflorescences alcoholic extract could serve as a protective agent in male reproductive male failures during Nic exposure in a rat model. Twenty-five adult male Wistar rats were categorized into the five groups. Tests 1 and 3 groups were received Nic at dose levels of 0.2 and 0.4mg/kg BW/day, respectively by IP injection. Tests 2 and 4 groups were received Nic at the same doses along with Achm at dose level of 120mg/kg BW/day. The study period took forty-eight days for all experimental groups. Nic groups showed significant decreases in tubule differentiation index (TDI), sperm count, motility, stereological parameters and an increase in dead and abnormal sperms. Moreover, the reduction in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, serum levels of FSH, LH and testosterone, along with increased serum concentration of LDH were observed in the Nic groups. Total nitrite and malondealdehyde levels incre...Continue Reading

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