Abstract
Metronidazole (MTZ), an anti-parasitic drug, induces negative effects on the testis. Curcumin exhibits antioxidant properties and anti-tumor properties. The aim was to evaluate negative effects of seminiferous tubules and Leydig cells by MTZ and ameliorative effects of curcumin. Balb/c mice were divided into six groups. The control, second, third, fourth and fifth, and sixth groups were administrated distilled water, high doses of MTZ (500 mg/kg/day), MTZ (500 mg/kg/day) +100 mg/kg/day curcumin, therapeutic doses of MTZ (165 mg/kg/day), MTZ (165 mg/kg/day) +100 mg/kg/day curcumin, and 100 mg/kg/day curcumin, respectively. The data revealed significant reduction in tubule volume, length and diameter and germinal epithelium height, and increase the number of Leydig cells in MTZ-treated (high or therapeutic doses) animals. Combined treatment of curcumin with high or therapeutic doses of MTZ ameliorated the increase in number of Leydig cell. Ameliorative effects of curcumin on the other above-mentioned parameters were observed in mice receiving therapeutic doses of MTZ. Leydig cell or nucleus volume and interstitial tissue volume did not show any significant difference in the MTZ-treated mice. It can be concluded that metronidazole...Continue Reading
References
Apr 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R M McClainJ E Edgcomb
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Oct 1, 1986·Journal of Neuroscience Methods·H Braendgaard, H J Gundersen
May 1, 1984·Journal of Microscopy·D C Sterio
Jul 1, 1995·Human & Experimental Toxicology·D E Prentice, A W Meikle
Nov 14, 1997·Drugs·C D FreemanK C Lamp
Apr 23, 1999·Critical Reviews in Toxicology·J C CookP M Foster
May 8, 1999·Journal of the American Society of Nephrology : JASN·J R Nyengaard
Jul 29, 2003·Journal of Applied Toxicology : JAT·Lars H PedersenMark J West
May 1, 2004·Critical Reviews in Food Science and Nutrition·B JoeB R Lokesh
May 6, 2004·Basic & Clinical Pharmacology & Toxicology·Abeer F el-Nahas, Ibrahim M el-Ashmawy
Dec 23, 2006·Reproductive Toxicology·Marta D MudryMarta A Carballo
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Ebenezer Olatunde FarombiMatthew O Oyeyemi
Jan 1, 2008·Fertility and Sterility·Neeta Mathuria, Ramtej Jayram Verma
Jan 29, 2008·Fertility and Sterility·Si-Ming WeiJian Zhou
Jul 22, 2008·Acta Neuropathologica·Karl-Anton Dorph-PetersenDavid A Lewis
Aug 30, 2008·Chemico-biological Interactions·Dipak Kumar SahooGagan B N Chainy
Dec 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatma M El-DemerdashFatma M E Radwan
Jan 16, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christian MühlfeldTerry M Mayhew
Mar 13, 2009·Human Reproduction·Yusuf Ozlem IlbeyAdnan Somay
Jun 26, 2009·Journal of Natural Medicines·Jian-Chang ShuLe-Xin Wang
Citations
Oct 17, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ali Noorafshan
May 12, 2012·Reproductive Toxicology·Caitlin J MurphyWilliam J Murdoch
Aug 30, 2012·Molecular Nutrition & Food Research·Mehmet KanterMustafa Erboga
Jul 26, 2013·Bulletin of Environmental Contamination and Toxicology·Junyan HanGuangchun Liu
Nov 12, 2019·Journal of Food Biochemistry·Seun F Akomolafe, Bukola T Aluko
Jan 31, 2020·Human & Experimental Toxicology·M H HassanE Abdel-Kahaar
Nov 24, 2016·Reproduction, Fertility, and Development·Zina M Al-AlamiMutasem O Taha
Apr 5, 2018·Scientific Reports·Kai SteinfeldRalf Middendorff
Nov 6, 2021·Pharmacological Reports : PR·Camila de Oliveira PachecoSandra Elisa Haas