Ameliorative Effects of Honey, Propolis, Pollen, and Royal Jelly Mixture against Chronic Toxicity of Sumithion Insecticide in White Albino Rats.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Atef M K NassarGaber El-Saber Batiha

Abstract

Sumithion (Fenitrothion) (SUM) is an organophosphorus insecticide used to combat a wide variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney, and reproductive organs through, for example, binding to DNA, and it induces DNA damage, which ends with oxidative stress. Therefore, the present study aimed to examine the protective role of bee products: a mixture of honey, propolis, palm pollen, and royal jelly (HPPJ) against SUM-induced toxicity. Twenty-four male albino rats (Rattus norvegicus) were classified into four groups, each containing six rats: control (corn oil), SUM (85 mg/kg; 1/20 LD50), HPPJ, and SUM + HPPJ once daily for 28 consecutive days. Blood samples were gently collected in sterilized ethylenediaminetetraacetic acid (EDTA) tubes for blood picture analyses and tubes without anticoagulant for serum isolation. Serum was used for assays of enzymatic and biochemical characteristics. The results revealed that SUM increased the weights of the liver, kidney, and brain as well as the enzymatic activity of glutathione peroxidase (GP), serum superoxide dismutase (SOD), and glutathione-S-transferase (GST). Additionally, SUM significantly increased the activity of lactate dehydrogenase...Continue Reading

References

Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BartelsC Heierli
Jan 1, 1983·Journal of Comparative Pathology·A K Srivastava, J Mishra
Jan 1, 1996·Free Radical Biology & Medicine·S A van AckerA Bast
Jul 9, 2002·Human & Experimental Toxicology·I SahinT Noyan
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Feb 25, 2005·Nature Reviews. Drug Discovery·Frank E Koehn, Guy T Carter
Feb 9, 2006·Neurotoxicity Research·Jucéla J FortunatoJoão Quevedo
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Salud García-AyllónJavier Sáez-Valero
Feb 25, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Levent AvsarogullariMurat Yücei
Dec 25, 2008·Toxicology and Industrial Health·S AfsharM Ilkhanipour
Nov 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suna KalenderYusuf Kalender
May 19, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanaa A Hassan, Mokhtar I Yousef
Jun 10, 2010·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·O O ErejuwaMd Salzihan Md Salleh
Mar 23, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatma M El-Demerdash
Apr 26, 2011·Ecotoxicology and Environmental Safety·Saoudi MongiEl Feki Abdelfattah
Oct 22, 2011·Asian Pacific Journal of Tropical Medicine·Simplice D KarouJacques Simpore
Nov 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Natalia S S GuimarãesTiago Rodrigues
Jun 26, 2012·Toxicology·Antonio F HernándezOlga López-Guarnido
Jul 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Nor Hayati Othman
Jul 28, 2012·Annals of Surgery·Lisette T HoekstraThomas M van Gulik
May 28, 2013·Arhiv za higijenu rada i toksikologiju·Ali Akbar MalekiradMohammad Abdollahi
Dec 11, 2013·International Journal of Endocrinology·Kalaivani BatumalaieRajes Qvist
Dec 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Sarfraz Ahmed, Nor Hayati Othman
Oct 1, 2012·Journal of Traditional and Complementary Medicine·Nor Hayati Othman
Jun 4, 2014·International Journal of Molecular Sciences·Miroslav Pohanka
Aug 7, 2014·Environmental Science and Pollution Research International·Lian-Jun BaoEddy Y Zeng
Dec 6, 2014·Oxidative Medicine and Cellular Longevity·Antonio Ivanildo PinhoJeferson Luis Franco

❮ Previous
Next ❯

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Gaber El-Saber BatihaHelal F Hetta

❮ Previous
Next ❯

Software Mentioned

Statistical Analysis System ( SAS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.