Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Radu IonitaLucian Hritcu

Abstract

Matricaria chamomilla L. is a medicinal herb traditionally used as the anti-inflammatory, antimicrobial, antiviral, anxiolytic and antidepressant agent. Nevertheless, supporting evidence demonstrated its memory enhancing activity and antioxidant properties. To investigate the effects of the hydroalcoholic extract of M. chamomilla L. on memory processes in a scopolamine-induced a rat model of amnesia and to reveal its underlying mechanism of action. The hydroalcoholic extract (25 and 75 mg/kg) was intraperitoneally administered to rats once daily for 7 days, and scopolamine (0.7 mg/kg) was injected 30 min before the behavioral testing to induce memory impairment. The phytochemical composition of the extract was quantified by HPLC/DAD analysis. Y-maze and radial arm-maze tests were employed for memory assessing. Acetylcholinesterase activity was measured in the rat hippocampus. Superoxide dismutase, glutathione peroxidase, and catalase specific activities along with the total content of reduced glutathione and protein carbonyl and malondialdehyde levels were also measured in the rat hippocampus. qRT-PCR was used to quantify BDNF mRNA and IL1β mRNA expression in the rat hippocampus. We first identified the chlorogenic acid, apigen...Continue Reading

Citations

Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elahe PiriDezső Csupor
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Razvan Stefan BoiangiuOana Cioanca
Jul 14, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gang DengChanghong Wang
Jun 8, 2021·Critical Reviews in Food Science and Nutrition·Sajad FakhriHaroon Khan

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