Ameliorative Effects of Selenium on Cadmium-Induced Injury in the Chicken Ovary: Mechanisms of Oxidative Stress and Endoplasmic Reticulum Stress in Cadmium-Induced Apoptosis

Biological Trace Element Research
Na WanS Li

Abstract

Despite the well-established toxicity of cadmium (Cd) to animals and the ameliorative effects of selenium (Se), some specific mechanisms in the chicken ovary are not yet clarified. To explore the mechanism by which the toxicity effect of Cd is induced and explore the effect of supranutritional Se on Cd toxicity in female bird reproduction, forty-eight 50-day-old Isa Brown female chickens were divided randomly into four groups. Group I (control group) was fed the basic diet containing 0.2 mg/kg Se. Group II (Se-treated group) was fed the basic diet supplemented with sodium selenite (Na2SeO3), and the total Se content was 2 mg/kg. Group III (Se + Cd-treated group) was fed the basic diet supplemented with Na2SeO3; the total Se content was 2 mg/kg, and it was supplemented with 150 mg/kg cadmium chloride (CdCl2). Group IV (Cd-treated group) was with the basic diet supplemented with 150 mg/kg CdCl2. The Cd, estradiol (E2), and progestogen (P4) contents changed after subchronic Cd exposure in chicken ovarian tissue; subsequently, oxidative stress occurred and activated the endoplasmic reticulum (ER) pathway to induce apoptosis. Further, Se decreased the accumulation of Cd in ovarian tissue, increased the E2 and P4 contents, alleviated...Continue Reading

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Citations

Jan 27, 2019·Bulletin of Environmental Contamination and Toxicology·Shun Long MengPao Xu
Dec 14, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhe LiuRui Wu
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Jan 7, 2021·Biological Trace Element Research·Indrajit Kar, Amlan Kumar Patra
Dec 29, 2020·Ecotoxicology and Environmental Safety·Zhang YimingLi Shu
Jan 8, 2021·Molecular Human Reproduction·Miyuki HaradaYutaka Osuga
Feb 5, 2021·Environmental Pollution·Zijiang YangShiwen Xu
Feb 6, 2021·Molecular Human Reproduction·Miyuki HaradaYutaka Osuga
Aug 11, 2020·Research in Veterinary Science·Yumei LiuZiqiang Zhang
Aug 28, 2021·International Journal of Environmental Research and Public Health·Halina B RöllinJon Øyvind Odland

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Datasets Mentioned

BETA
L08165.1

Methods Mentioned

BETA
protein assay
Assay
acid digest
ELISA
MDA
PCR
reverse
electrophoresis
transmission electron microscopy

Software Mentioned

graph pad prism
GraphPad
Prime

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis