Ameliorative effects of taurine against diabetes: a review.

Amino Acids
Inam-U-LlahZulfiqar Ahmed

Abstract

Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control. Taurine has been observed to be effective in treatments against diabetic hepatotoxicity, vascular problems and heart injury in diabetes. Taurine was shown to be effective against oxidative stress. The mechanism of action of taurine cannot be explained by one pathway, as it has many effects. Several of the pathways are the advanced glycation end-product pathway, PI3-kinase/AKT pathway and mitochondrial apoptosis pathway. The worldwide threat of diabetes underscores the urgent need for novel therapeutic measures against this disorder. Taurine (2-aminoethane sulfonic acid) is a natural compound that has been studied in diabetes and diabetes-induced complications.

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Citations

Sep 29, 2019·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Oct 1, 2020·Food Science & Nutrition·Tahniat RehmanRana Muhammad Aadil
Jun 21, 2018·Journal of Proteome Research·João C P SilvaAna M Gil

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Methods Mentioned

BETA
amputations
MDA
protein folding

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