Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease

Journal of Ethnopharmacology
M TabuchiYoshio Kase

Abstract

Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease. Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances. Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice. These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice.

References

Dec 16, 2004·Behavioral Neuroscience·Philip BarnesMark Good
Dec 2, 2005·The New England Journal of Medicine·Philip S WangM Alan Brookhart
Feb 2, 2006·Neurobiology of Aging·Joseph F QuinnRobert W Stackman
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·J Steven JacobsenFloyd E Bloom
Aug 1, 2006·Lancet·Kaj BlennowHenrik Zetterberg
Aug 31, 2006·Behavioural Pharmacology·Walter AdrianiGiovanni Laviola
Jan 19, 2007·Behavioural Brain Research·Perdita L PughDavid Sunter
Aug 25, 2007·Pharmacology & Therapeutics·Mark A Findeis

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Citations

Nov 2, 2011·Cellular and Molecular Neurobiology·Yan-Fang XianXiao-Ping Lai
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Dec 29, 2011·Neural Plasticity·Tara Spires-Jones, Shira Knafo
Jul 26, 2013·Journal of Pharmacological Sciences·Kinzo MatsumotoJun-Ichiro Oka
Jun 19, 2013·Journal of Ethnopharmacology·Hirotaka Shoji, Kazushige Mizoguchi
Apr 26, 2011·Journal of Ethnopharmacology·Marina YamadaKinzo Matsumoto
Mar 14, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ping LiuPing Wang
Oct 3, 2018·Biological & Pharmaceutical Bulletin·Kagaku AzumaKin-Ya Kubo
Sep 3, 2010·Phytotherapy Research : PTR·S de Caires, V Steenkamp
Nov 11, 2011·CNS Neuroscience & Therapeutics·Elaine Perry, Melanie-Jayne R Howes
Mar 1, 2020·Medicina·Piergiacomo BusoAnna Baldisserotto
Jun 2, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Motohiro OzoneMasahiro Shigeta
Jan 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takashi MatsumotoMasahiro Yamamoto
Oct 6, 2017·Frontiers in Pharmacology·Kazushige Mizoguchi, Yasushi Ikarashi
Jan 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jung-Hee JangChangjong Moon
Mar 20, 2019·Expert Review of Neurotherapeutics·Rohit SharmaP K Prajapati
Oct 27, 2020·Stem Cells International·Provvidenza M AbruzzoCarlo Ventura
Aug 23, 2019·Aging and Disease·Seong Gak JeonMinho Moon
Dec 6, 2019·Journal of Natural Products·Qiang GuoQingying Zhang

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