Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Pandima Devi Sampath, Kannan Vijayaragavan

Abstract

Altered membrane integrity and inflammation play a key role in cardiovascular damage. We investigated the salubrious effect of exogenously administered alpha-mangostin against beta-adrenergic cathecolamine-induced cardiovascular toxicity with special reference to membrane ATPases, lysosomal hydrolases and inflammatory mediators TNF-alpha and Cyclooxygenase-2 (COX-2) expressions in albino rats. Induction of rats with isoproterenol (150mg/kg body wt, i.p.) for 2 days resulted in a significant increase in the activities of serum and cardiac lysosomal hydrolases (beta-d-glucuronidase, beta-d-galactosidase, beta-d-N-acetylglucosaminidase, acid phosphatase and cathepsin-D). A significant increase in cardiac levels of sodium, calcium with a decrease in the level of potassium paralleled by abnormal activities of membrane-bound phosphatases (Na(+)-K(+) ATPase, Ca(2+) ATPase and Mg(2+) ATPase) were observed in the heart of ISO-administered rats. Cardiac TNF-alpha and COX-2 expressions were assessed by Western blotting. Cardiac TNF-alpha and COX-2 expressions were significantly elevated in ISO-intoxicated rats. Pre-co-treatment with alpha-mangostin (200mg/kg body wt.) orally for 8 days significantly attenuated these abnormalities and rest...Continue Reading

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Citations

May 11, 2012·Journal of Clinical Biochemistry and Nutrition·Gadham Setty Saayi KrushnaLakshmi Devi Kodidhela
Mar 19, 2014·Journal of Radiation Research·Yuanyuan RanHong Qing
Nov 6, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Shreesh OjhaDharamvir Singh Arya
Oct 30, 2016·European Journal of Pharmacology·K L Hemalatha, P Stanely Mainzen Prince
Jun 8, 2017·Journal of Biochemical and Molecular Toxicology·Sukanya PhungphongSunit Suksamrarn
Jun 29, 2017·Phytotherapy Research : PTR·Hourieh Tousian ShandizHossein Hosseinzadeh
Jan 22, 2011·Molecular Nutrition & Food Research·Li LiVeronika Butterweck
Feb 9, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Urmila AswarManoj Aswar
Feb 20, 2021·European Journal of Pharmacology·Aihong YangRui Shen
Dec 29, 2021·Phytotherapy Research : PTR·Farhad EisvandHossein Hosseinzadeh

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