Ameliorative role of ferulic acid against diabetes associated oxidative stress induced spleen damage

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sumit GhoshParames C Sil

Abstract

Spleen, a secondary lymphoid organ, is the site of initiation of most of the immune responses. The present study is centered on the ameliorative role of ferulic acid against diabetic complications in the spleen of male Wistar rats. Induction of diabetes by STZ (at a dose of 50 mg kg-1 body wt, i.p.) reduced the spleen size, plasma insulin level, enhanced the blood glucose level and disrupted the intracellular antioxidant machineries along with the depletion of splenic white pulp. Induction of oxidative stress mediated inflammation and apoptosis (upregulation in the levels of inflammatory cytokines, translocation of NF ĸB in the nucleus, alteration in Bax/Bcl-2 ratio, release of cytochrome c from mitochondria, activation of caspase-9 and 3, PARP cleavage and DNA fragmentation) were evidenced from immunoblot analyses, DNA fragmentation and TUNEL assay. However, ferulic acid administration post diabetes induction, (at a dose of 50 mg kg-1 body wt, orally for eight weeks) could reverse such adverse effects. Therefore, ferulic acid, as a potential therapeutic agent may hold promise in evading oxidative stress mediated diabetic splenotoxicity in rats.

Citations

Sep 7, 2019·Journal of Clinical Medicine·Estefania Burgos-MorónVíctor M Víctor
Nov 2, 2019·Organic & Biomolecular Chemistry·Daniel ChavarriaFernanda Borges
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Aug 29, 2019·Critical Reviews in Food Science and Nutrition·Anurag Khatkar, Krishna Kant Sharma
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jiahui WeiYi Chen
May 20, 2019·Environmental Science and Pollution Research International·Sanasam SanjeevVikas Kumar Roy
Dec 17, 2020·Journal of Biochemical and Molecular Toxicology·Fatemeh YarmohammadiGholamreza Karimi
Jan 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Syed Afroz AliVenu Talla
Sep 12, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Uday HossainParames C Sil
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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