Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons.

Cells
Pierfrancesco PagellaThimios A Mitsiadis

Abstract

Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity. Few studies have addressed the cellular and molecular events of ameloblastoma onset and progression, thus hampering the development of non-invasive therapeutic approaches. Tumorigenesis is driven by a plethora of factors, among which innervation has been long neglected. Recent findings have shown that innervation directly promotes tumor progression. On this basis, we investigated the molecular characteristics and neurotrophic properties of human ameloblastomas. Our results showed that ameloblastomas express dental epithelial stem cell markers, as well as components of the Notch signaling pathway, indicating persistence of stemness. We demonstrated that ameloblastomas express classical stem cell markers, exhibit stem cell potential, and form spheres. These tumors express also molecules of the Notch signaling pathway, fundamental for stem cells and their fate. Additionally, we showed that ameloblastomas express the neurotrophic factors NGF and BDNF, as well as their receptors TRKA, TRKB, and P75/NGFR, which are responsible for their innervation by trigeminal axons in vi...Continue Reading

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Citations

Jan 7, 2021·Oral Diseases·Ayelet Zlotogorski-HurvitzMarilena Vered
Nov 7, 2020·Biochemical Society Transactions·Pierfrancesco PagellaThimios A Mitsiadis
Mar 9, 2021·Case Reports in Plastic Surgery & Hand Surgery·Abelardo MedinaRavi Chandran

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Methods Mentioned

BETA
PCR
PCRs
biopsy
biopsies
confocal microscopy

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