Amenorrhea after lung cancer treatment

Menopause : the Journal of the North American Menopause Society
Elizabeth J Cathcart-RakePing Yang

Abstract

More than 5,000 premenopausal women are diagnosed with lung cancer annually in the United States. Limited data exist regarding the risk of treatment-related amenorrhea, a surrogate for infertility and early menopause, after systemic therapies for lung cancer. Premenopausal women diagnosed with lung cancer under age 50 were surveyed at diagnosis and annually thereafter about their menstrual status as a part of the Mayo Clinic Epidemiology and Genetics of Lung Cancer Research Program. Types of lung cancer-directed treatments were recorded, and frequencies of self-reported menopause at each survey were calculated. A cohort of 182 premenopausal women were included in this study, with average age at lung cancer diagnosis 43 years (SD 6). Among the 85 patients who received chemotherapy, 64% self-reported that they had become menopausal within a year of diagnosis. Platinum salts were universally included in these chemotherapy regimens, and the majority of these women also received taxanes within 1 year of diagnosis. Only 15% of the 94 patients who did not receive systemic therapy within 1 year of diagnosis experienced self-reported menopause. Three patients received targeted therapy alone, two of whom remained premenopausal at the fin...Continue Reading

References

May 15, 1985·Cancer·S V NicosiaA T Meadows
Apr 1, 1971·The American Journal of Medicine·J J MillerJ C Leissring
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J CouziJ H Fetting
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BinesM A Cobleigh
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J GoodwinN Hood
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karolin BehringerUNKNOWN German Hodgkin's Lymphoma Study Group
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michelle JamnongjitStephen R Hammes
Nov 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janice M WalsheSandra M Swain
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David M GershensonUNKNOWN Gynecologic Oncology Group
Feb 28, 2008·Breast Cancer Research and Treatment·Sandra M SwainPatricia A Ganz
Mar 14, 2009·Journal of Women's Health·Megan E B ClowseLori A Bastian
Feb 2, 2010·Reproductive Biomedicine Online·Christine DecanterDidier Dewailly
Nov 5, 2010·Clinical Obstetrics and Gynecology·Dror MeirowW Hamish B Wallace
Feb 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Richard A Anderson, David A Cameron
Dec 3, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ping YangJeff A Sloan
Dec 6, 2011·Fertility and Sterility·Clarisa R GraciaJill P Ginsberg
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanPing Yang
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn J Ruddy, Ann H Partridge
Nov 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle DemeestereYvon Englert
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karolin BehringerPeter Borchmann
Jan 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Akira IwaseFumitaka Kikkawa
May 17, 2013·Science Translational Medicine·Lital Kalich-PhilosophDror Meirow
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alison W LorenUNKNOWN American Society of Clinical Oncology
Aug 21, 2014·Journal of the National Cancer Institute·Anthony J SwerdlowUNKNOWN England and Wales Hodgkin Lymphoma Follow-up Group
Mar 5, 2015·The New England Journal of Medicine·Halle C F MooreUNKNOWN POEMS/S0230 Investigators
May 20, 2015·Breast Cancer Research and Treatment·Kathryn J RuddySara M Tolaney
Dec 15, 2015·Fertility and Sterility·Melanie H JacobsonPenelope P Howards
Dec 19, 2015·Fertility and Sterility·Hadassa RonessDror Meirow
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lea K KrekowJoyce O'Shaughnessy
Oct 27, 2017·The New England Journal of Medicine·Jacques Donnez, Marie-Madeleine Dolmans
Nov 9, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A AndersonR C F Leonard

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Citations

May 3, 2019·Lung Cancer Management·Fahad FaruqiKathryn J Ruddy
Apr 24, 2020·Journal of Cancer Survivorship : Research and Practice·Anat ChemerinskiClarisa Gracia

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