PMID: 11913408Mar 27, 2002Paper

Amenorrhea frequency with continuous combined hormone replacement therapy: a retrospective analysis. Menopause Study Group

Climacteric : the Journal of the International Menopause Society
J H PickarD F Archer

Abstract

The study retrospectively determined in postmenopausal women the cumulative amenorrhea patterns with continuous conjugated equine estrogens (CE) with or without continuous medroxyprogesterone acetate (MPA), and withdrawal bleeding patterns with cyclic therapy. During a 1-year, prospective trial, all patients took CE. Groups A and B also took continuous MPA 2.5 and 5 mg, respectively, C and D took MPA 5 and 10 mg for the last 14 cycle days, respectively, and E took placebo to match MPA. By cycle 7, 40.4, 52.6 and 53.8% of women in Groups A, B and E, respectively, became amenorrheic. Percentages increased at each subsequent cycle. Of the remaining women in Groups A and B, 42.1 and 46.2%, respectively, experienced only spotting at cycle 7. In Groups C and D, 80 and 65.9%, respectively, had a mean change of equal to or less than 3 days in the onset of withdrawal bleeding/spotting from cycle to cycle for all 13 evaluable cycles. Amenorrhea is often desirable, and a continuous combined daily regimen of CE 0.625 mg + MPA 2.5 or 5 mg, which resulted in progressive increases in amenorrheic frequency during the 1-year treatment period, may promote compliance. In some women, however, the cyclic regimens, which produced fairly predictable ...Continue Reading

References

May 1, 1991·American Journal of Obstetrics and Gynecology·U MarslewC Christiansen
Jun 1, 1990·American Journal of Obstetrics and Gynecology·L WeinsteinJ C Gallagher
May 1, 1987·American Journal of Obstetrics and Gynecology·V A Ravnikar
Jul 19, 1993·The Medical Journal of Australia·A H MacLennanK Eckert
Sep 1, 1995·Maturitas·P Eiken, N Kolthoff

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Citations

Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·F E Riphagen
Jan 19, 2008·Climacteric : the Journal of the International Menopause Society·D W SturdeeUNKNOWN CHOICE Study Investigators
Jan 21, 2015·Climacteric : the Journal of the International Menopause Society·L-Å MattssonUNKNOWN Study Group
May 29, 2004·Menopause : the Journal of the North American Menopause Society·Lise WarmingClaus Christiansen
Sep 8, 2020·Climacteric : the Journal of the International Menopause Society·J H PickarS Mirkin

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