Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation

In Vivo
Kun-Ching LeeFei-Ting Hsu

Abstract

The aim of the present study was to confirm therapeutic efficacy and find probable mechanism of action of amentoflavone in hepatocellular carcinoma (HCC) in vivo. Luciferase reporter vector pGL4.50_transfected SK-Hep1 (SK-Hep1/luc2) tumor-bearing mice were treated with vehicle or amentoflavone (100 mg/kg/day by gavage) for 14 days. Tumor growth, amentoflavone toxicity, and extracellular signal-regulated kinase (ERK)/nuclear factor-kappaB (NF-ĸB) signaling in tumor progression were evaluated with digital caliper, bioluminescence imaging, computed tomography, body weight, pathological examination of liver, and immunohistochemistry staining. Amentoflavone significantly inhibited tumor growth, ERK/NF-ĸB activation, and expression of tumor progression-associated proteins as compared to vehicle-treated group. In addition, body weight and liver morphology of mice were not influenced by amentoflavone treatment. These results suggest that amentoflavone inhibits HCC progression through suppression of ERK/NF-ĸB signaling.

Citations

May 18, 2019·The American Journal of Chinese Medicine·Fei-Ting HsuJing-Gung Chung
Aug 23, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Fei ShenJing Xu
Feb 4, 2021·Natural Products and Bioprospecting·Jean-François GoossensChristian Bailly
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Yasmin Silva RizkKátia da Silva Calabrese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.