Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects

Neural Regeneration Research
Zhen ZhangFeng Wang

Abstract

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.

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Citations

Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sheng YuSam Fong Yau Li
Jan 5, 2017·Biological & Pharmaceutical Bulletin·Xiaoran ZhaoJianfeng Wang
Jan 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fatahiya Mohamed TapNurul Bahiyah Ahmad Khairudin
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Nov 11, 2020·Nutrients·Dominika KajszczakAnna Podsędek
Feb 16, 2021·Journal of Biomolecular Structure & Dynamics·Anshuman ChandraVikrant Nain
Aug 24, 2020·Fitoterapia·Paulo Anastácio Furtado PachecoRobson Xavier Faria
Aug 7, 2021·Journal of Biomolecular Structure & Dynamics·Meenakshi Chaudhary, Deepak Sehgal
Dec 17, 2020·Journal of Agricultural and Food Chemistry·Baolin WangHao Wang
Aug 28, 2021·Biomolecules·Naiara Naiana DejaniDamião Pergentino de Sousa
Oct 16, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shareen Singh, Thakur Gurjeet Singh

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Methods Mentioned

BETA
ELISA
electrophoresis
nuclear translocation

Software Mentioned

Pro
NeuroExplorer
Alpha
Image
- Pro analyzer
Gel
Pro Plus
Lab
Pro analyzer

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