American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain

International Immunopharmacology
Chong-Zhi WangChun-Su Yuan

Abstract

Inflammatory bowel disease (IBD) is a significant public health problem in the United States. Abdominal pain is a major complaint among individuals with IBD. Successful IBD management not only controls enteric inflammation, but also reduces abdominal discomfort. Recently, increased attention has been focused on alternative strategies for IBD management. HPLC/Q-TOF-MS analysis was employed to evaluate the intestinal microbiome's biotransformation of parent American ginseng compounds into their metabolites. Using a DSS mouse model, the effects of American ginseng microbial metabolites on chemically induced colitis was investigated with disease activity index and histological assessment. Expressions of inflammatory cytokines were determined using real-time PCR and ELISA. Abdominal pain was evaluated using the von Frey filament test. After the gut microbiome's biotransformation, the major metabolites were found to be the compound K and ginsenoside Rg3. Compared with the DSS animal group, American ginseng treatment significantly attenuated experimental colitis, as supported by the histological assessment. The enteric microbiome-derived metabolites of ginseng significantly attenuated the abdominal pain. American ginseng treatment sig...Continue Reading

Citations

Mar 4, 2020·Applied Microbiology and Biotechnology·Wei-Na Li, Dai-Di Fan
Jan 20, 2021·Pharmacological Reports : PR·Zengping KangDuanyong Liu
Aug 3, 2021·Frontiers in Pharmacology·Linshan DuanGuoyan Liu

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