American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine

CA: a Cancer Journal for Clinicians
Michael W Kattanmembers of the AJCC Precision Medicine Core

Abstract

The American Joint Committee on Cancer (AJCC) has increasingly recognized the need for more personalized probabilistic predictions than those delivered by ordinal staging systems, particularly through the use of accurate risk models or calculators. However, judging the quality and acceptability of a risk model is complex. The AJCC Precision Medicine Core conducted a 2-day meeting to discuss characteristics necessary for a quality risk model in cancer patients. More specifically, the committee established inclusion and exclusion criteria necessary for a risk model to potentially be endorsed by the AJCC. This committee reviewed and discussed relevant literature before creating a checklist unique to this need of AJCC risk model endorsement. The committee identified 13 inclusion and 3 exclusion criteria for AJCC risk model endorsement in cancer. The emphasis centered on performance metrics, implementation clarity, and clinical relevance. The facilitation of personalized probabilistic predictions for cancer patients holds tremendous promise, and these criteria will hopefully greatly accelerate this process. Moreover, these criteria might be useful for a general audience when trying to judge the potential applicability of a published...Continue Reading

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Citations

Feb 22, 2017·CA: a Cancer Journal for Clinicians·Mark K BuyyounouskiDaniel W Lin
Apr 5, 2018·Annals of Surgical Oncology·Martin R Weiser
Feb 23, 2018·Annals of Surgical Oncology·Emily C ZaborKatherine S Panageas
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