American Registry of Pathology Expert Opinions: Immunohistochemical evaluation of classic Hodgkin lymphoma

Annals of Diagnostic Pathology
Dennis P O'MalleyMohamed E Salama

Abstract

The diagnosis of classic Hodgkin lymphoma requires immunohistochemical confirmation in most cases and one can argue for these studies as standard-of-care in the diagnostic workup. The authors propose a panel of studies for primary identification of CHL to include: CD3, CD20, CD15, CD30 and PAX5. When pattern discordances are identified, additional assessment is recommended. In the case of overexpression of B lineage markers by Hodgkin/Reed-Sternberg cells, or a differential diagnosis that includes large B-cell lymphoma or variants, additional markers recommended are: CD45, OCT2, BOB1, CD79a and MUM1/IRF4. If primary mediastinal large B cell lymphoma is considered in the differential diagnosis, suggested additional markers include: P63, CD23, CD45 and CD79a. When considering a differential diagnosis that includes anaplastic large cell lymphoma we suggest: ALK, CD45, pan T cell antigens (such as CD2, CD5, CD7, and CD43), and cytotoxic markers (granzyme, perforin, and TIA1). If peripheral T cell lymphoma or T cell lymphomas of follicular helper origin are considered in the differential diagnosis, the following panel is recommended: pan T cell antigens, CD4, CD8, one or more follicular dendritic cell markers, and assessment for Eps...Continue Reading

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Citations

Dec 4, 2019·Diagnostic Cytopathology·Alessa AragaoStefan E Pambuccian
Dec 3, 2020·Diagnostics·Paola ParentePaolo Graziano
Jan 9, 2021·Diagnostic Cytopathology·Saeed AsiryLaleh Hakima
Apr 5, 2021·Journal of the American Society of Cytopathology : JASC·Ahmed ShahMonalisa Sur
Jun 28, 2021·Seminars in Diagnostic Pathology·Xiaoqiong WangAndres E Quesada
Jun 15, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Pietro BertoglioAlberto C Terzi
Jun 3, 2021·Advances in Anatomic Pathology·Sergio Pina-Oviedo

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