American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure.

Anais Brasileiros De Dermatologia
Sílvio Alencar MarquesMariangela Esther Alencar Marques

Abstract

Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.

References

Jan 30, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Juliana Saboia Fontenele e SilvaMarcus Tolentino Silva
Jan 18, 2017·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·H Kaaroud El JeriT Ben Abdallah
Apr 12, 2018·Revista da Associação Médica Brasileira·Laís AnversaLuis Eduardo Ramirez

❮ Previous
Next ❯

Citations

Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeysson Sánchez-SuárezEricsson Coy-Barrera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.