Amerindian genetic ancestry and INDEL polymorphisms associated with susceptibility of childhood B-cell Leukemia in an admixed population from the Brazilian Amazon

Leukemia Research
Darlen C CarvalhoNey P C Dos Santos

Abstract

Acute lymphoblastic leukemia (ALL) is a malignant tumor common in children. Studies of genetic susceptibility to cancer using biallelic insertion/deletion (INDEL) type polymorphisms associated with cancer development pathways may help to clarify etymology of ALL. In this study, we investigate the role of eight functional INDEL polymorphisms and influence of genetic ancestry to B-cell ALL susceptibility in children of Brazilian Amazon population, which has a high degree of inter-ethnic admixture. Ancestry analysis was estimated using a panel of 48 autosomal ancestry informative markers. 130 B-cell ALL patients and 125 healthy controls were included in this study. The odds ratios and 95% confidence intervals were adjusted for confounders. The results indicated an association between the investigated INDEL polymorphisms in CASP8 (rs3834129), CYP19A1 (rs11575899) e XRCC1 (rs3213239) genes in the development of B-cell ALL. The carriers of Insertion/Insertion (Ins/Ins) genotype of the polymorphism in CASP8 gene presented reduced chances of developing B-cell ALL (P=0.001; OR=0.353; 95% CI=0.192-0.651). The Deletion/Deletion (Del/Del) genotype of the polymorphism in CYP19A1 gene was associated to a lower chance of developing B-cell ALL...Continue Reading

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Citations

Jan 24, 2018·World Journal of Gastroenterology : WJG·Giovanna C CavalcanteSidney Santos
Dec 1, 2017·BMC Research Notes·Ellen Moreno da SilvaNey Pereira Carneiro Dos Santos
Jun 13, 2019·Genetics and Molecular Biology·Aracele Maria de SouzaCristiana Ferreira Alves de Brito
Jul 17, 2020·PloS One·Diana Feio da Veiga Borges LealNey Pereira Carneiro Dos Santos
Mar 25, 2020·International Journal of Molecular Sciences·Gleyce Fonseca CabralÂndrea Ribeiro-Dos-Santos
Nov 1, 2017·World Journal of Gastroenterology : WJG·Diego MarquesVivian Nogueira Silbiger
Oct 21, 2020·BMC Medical Genetics·Giovanna Chaves CavalcanteÂndrea Ribeiro-Dos-Santos
Dec 29, 2020·PloS One·André Salim KhayatSidney Emmanuel Batista Dos Santos

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