Ames positive boronic acids are not all eukaryotic genotoxins

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Heather Scott, Richard M Walmsley

Abstract

Boronic acids and their derivatives have been exploited for their pharmacological activity and their utility as intermediates in the synthesis of novel non-boron containing compounds. A recent study reported that boronic acids are bacterial mutagens. Here, results are reported from the testing of nine boronic acids using the pan-mechanistic eukaryotic GADD45a genotoxicity assays, BlueScreen HC and GreenScreen HC. Positive results were produced for one compound in GreenScreen and four compounds in BlueScreen. Only negative results were produced when tested with S9 metabolic activation. These data suggest that there is not a general genotoxic liability in eukaryotes, within this chemical domain. Furthermore, they are not potent eukaryotic genotoxins: positive results were produced only at concentrations between 1mM and 10mM. Their presence as low concentration contaminants or impurities would be unlikely to produce misleading positive results for a test material.

References

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Jul 14, 2009·Regulatory Toxicology and Pharmacology : RTP·Andrew W KnightRichard M Walmsley
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Citations

May 29, 2015·Chemical Research in Toxicology·Maria L PellizzaroRichard V Williams
Jun 23, 2016·Toxicology Letters·E D Farfán-GarcíaM A Soriano-Ursúa
Jun 29, 2018·Nanotoxicology·Eşref Demir, Ricard Marcos
May 4, 2018·Angewandte Chemie·Burcin Akgun, Dennis G Hall
Jan 25, 2021·Regulatory Toxicology and Pharmacology : RTP·Niels HadrupAnoop K Sharma
Oct 7, 2019·Regulatory Toxicology and Pharmacology : RTP·Curran LandryLidiya Stavitskaya
Nov 3, 2020·Molecular Metabolism·Thomas Hoeg-Jensen

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