Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide

Journal of the American Chemical Society
Yifeng ChenTimothy R Newhouse

Abstract

A practical and direct method for the α,β-dehydrogenation of amides is reported using allyl-palladium catalysis. Critical to the success of this process was the synthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan). The reaction conditions tolerate a wide variety of substrates, including those with acidic heteroatom nucleophiles.

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Citations

Apr 28, 2017·Journal of the American Chemical Society·Xian-He ZhaoChun-An Fan
Jun 3, 2017·Journal of the American Chemical Society·Ming Chen, Guangbin Dong
Feb 10, 2018·Angewandte Chemie·Ming ChenGuangbin Dong
Aug 22, 2017·Organic & Biomolecular Chemistry·Rajender NallagondaPrasanta Ghorai
Aug 11, 2017·Angewandte Chemie·Yizhou ZhaoTimothy R Newhouse
Oct 17, 2018·Angewandte Chemie·Ming ChenGuangbin Dong
Oct 18, 2018·Angewandte Chemie·Christopher J TeskeyNuno Maulide
Nov 18, 2018·Angewandte Chemie·Mark D ApareceJames P Morken
Jul 17, 2019·Angewandte Chemie·Xiwu ZhangYanxing Jia
Feb 8, 2020·Organic & Biomolecular Chemistry·Erika FutakiMasafumi Ueda
Oct 30, 2018·Chemistry : a European Journal·John A KellyCameron Jones
Feb 11, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhiyun Hu, Xinzheng Yang
Feb 13, 2021·Organic Letters·Xiao-Wei ZhangYan-Biao Kang
Feb 17, 2021·Accounts of Chemical Research·David Huang, Timothy R Newhouse
Mar 25, 2021·Nature Chemistry·Samer GnaimPhil S Baran
Mar 27, 2021·Angewandte Chemie·Guoli HeMathias Christmann
Jul 14, 2021·The Journal of Organic Chemistry·Biplab Keshari Pandia, Chidambaram Gunanathan
Feb 6, 2018·Journal of the American Chemical Society·Padon ChuentragoolVladimir Gevorgyan
Jan 18, 2018·Journal of the American Chemical Society·Alexander W SchuppeTimothy R Newhouse
Aug 27, 2019·Journal of the American Chemical Society·Ming Chen, Guangbin Dong
Jan 23, 2019·The Journal of Organic Chemistry·Toshikazu Hirao
Mar 13, 2019·Journal of the American Chemical Society·David HuangTimothy R Newhouse
Nov 4, 2017·Journal of the American Chemical Society·Daniel KaiserNuno Maulide
Apr 19, 2019·The Journal of Organic Chemistry·Michael J Zacuto
Aug 29, 2019·ACS Omega·Shicheng Shi, Michal Szostak
May 24, 2018·Organic Letters·Bing JiangTeck-Peng Loh
Jan 13, 2018·Organic Letters·David HuangTimothy R Newhouse
Oct 1, 2021·Journal of the American Chemical Society·Min-Jie ZhouZheng Huang

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