Amide-Directed Intramolecular Co(III)-Catalyzed C-H Hydroarylation of Alkenes for the Synthesis of Dihydrobenzofurans with a Quaternary Center

The Journal of Organic Chemistry
Asier Carral-MenoyoEsther Lete

Abstract

The first example of Cp*Co(III)-catalyzed intramolecular hydroarylation of allyl aryl ethers using an amide directing group for the preparation of 3,3-disubstituted dihydrobenzofurans in high yields is described. The reaction of the unactivated alkene is completely selective for the formation of the quaternary center, allowing different substitution patterns on the aromatic ring and the alkene. The cyclization can also be extended to the formation of six-membered rings and to N-homoallylindoles.

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Citations

Jan 6, 2021·Organic & Biomolecular Chemistry·Kana Sakamoto, Takahiro Nishimura
Aug 17, 2021·Chemical Communications : Chem Comm·Bhargav DesaiTogati Naveen
Sep 28, 2021·Chemical Communications : Chem Comm·Lukass LukasevicsLiene Grigorjeva

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