Amide-induced phase separation of hexafluoroisopropanol-water mixtures depending on the hydrophobicity of amides

Physical Chemistry Chemical Physics : PCCP
Toshiyuki TakamukuMunetaka Takeuchi

Abstract

Amide-induced phase separation of hexafluoro-2-propanol (HFIP)-water mixtures has been investigated to elucidate solvation properties of the mixtures by means of small-angle neutron scattering (SANS), (1)H and (13)C NMR, and molecular dynamics (MD) simulation. The amides included N-methylformamide (NMF), N-methylacetamide (NMA), and N-methylpropionamide (NMP). The phase diagrams of amide-HFIP-water ternary systems at 298 K showed that phase separation occurs in a closed-loop area of compositions as well as an N,N-dimethylformamide (DMF) system previously reported. The phase separation area becomes wider as the hydrophobicity of amides increases in the order of NMF < NMA < DMF < NMP. Thus, the evolution of HFIP clusters around amides due to the hydrophobic interaction gives rise to phase separation of the mixtures. In contrast, the disruption of HFIP clusters causes the recovery of the homogeneity of the ternary systems. The present results showed that HFIP clusters are evolved with increasing amide content to the lower phase separation concentration in the same mechanism among the four amide systems. However, the disruption of HFIP clusters in the NMP and DMF systems with further increasing amide content to the upper phase sepa...Continue Reading

References

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Mar 12, 2010·The Journal of Physical Chemistry. B·Toshiyuki TakamukuMunetaka Takeuchi
May 17, 2011·Physical Chemistry Chemical Physics : PCCP·Toshiyuki TakamukuRyo Kanzaki
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Citations

Oct 1, 2014·Physical Chemistry Chemical Physics : PCCP·Toshiyuki TakamukuTakuya Shimomura
Aug 21, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Toshiyuki TakamukuTatsuya Umecky
Nov 5, 2013·Physical Chemistry Chemical Physics : PCCP·Takuya ShimomuraToshiyuki Takamuku
Jul 4, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Milan R MilovanovićJean-Pierre Djukic

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