Amide Proton Transfer MR Imaging of Endometrioid Endometrial Adenocarcinoma: Association with Histologic Grade

Radiology
Yukihisa TakayamaHiroshi Honda

Abstract

Purpose To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and Methods The institutional review board approved this prospective study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and -0.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% ± 0.2 (standard deviation), 0.9 × 10-3 mm2/sec ± 0.2, and 0.6 × 10-3 mm2/sec ± 0.1 for grade 1; 3.2% ± 0.3, 0.8 × 10-3 mm2/sec ± 0.1, and 0.5 × 10-3 mm2/sec ± 0.1 for grade 2; and 3.7% ± 0.3, 0.9 ×...Continue Reading

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Citations

Oct 21, 2018·Japanese Journal of Radiology·Kiyohisa KamimuraTakashi Yoshiura
Mar 13, 2019·Journal of Magnetic Resonance Imaging : JMRI·Yong-Lan HeZheng-Yu Jin
Mar 31, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steffen GoerkePeter Bachert
Sep 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ferdinand ZimmermannSteffen Goerke
May 20, 2020·Journal of Magnetic Resonance Imaging : JMRI·Fei JiaDongming Han
Jun 7, 2019·Scientific Reports·Yun Jung BaeJae Hyoung Kim
Dec 5, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sahrish QamarJing Yuan
Feb 23, 2020·NMR in Biomedicine·Johannes BreitlingSteffen Goerke
Oct 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shanshan JiangJinyuan Zhou
Nov 14, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yuan LiZheng-Yu Jin
May 28, 2020·European Journal of Radiology·Takeshi KamitaniHidetake Yabuuchi

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