Amidolytic heparin activity and values for several hemostatic variables after repeated subcutaneous administration of high doses of a low molecular weight heparin in healthy dogs

American Journal of Veterinary Research
R MischkeM Kietzmann

Abstract

To determine effects of SC administration of repeated doses of a low molecular weight heparin (LMWH) in dogs. 5 healthy dogs. Each dog received 6 injections (each injection, 150 U of anti-factor-Xa [anti-FXal/kg of body weight, SC) at 8-hour intervals. Blood samples were collected before and 2 hours after the first, second, third, and sixth injections to measure heparin activity, thrombin time, activated partial thromboplastin time (APTT), antithrombin activity, Hct, and platelet count. Heparin activity varied between 0.36+/-0.10 and 0.77+/-0.08 U of anti-FXa/ml (before and 2 hours after the third injection) and between 0.46+/-0.11 and 0.82+/-0.15 U of anti-FXa/ml (before and 2 hours after the sixth injection). Thrombin time and APTT were influenced only slightly. Platelet count, Hct, and antithrombin activity started to decrease significantly 2 hours after the second LMWH injection. Because of the increased consumption of antithrombin, antithrombin activity continuously decreased from 102.1+/-6.3% before the study to 91.0+/-3.0% at the end of the study. Heparin plasma activity was only slightly higher than that recommended for LMWH treatment of humans, and none of the dogs had signs of increased bleeding. Thus, administration ...Continue Reading

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Citations

Nov 4, 2004·Journal of the American Veterinary Medical Association·Caren E SmithJohn E Rush
Feb 19, 2016·Journal of Veterinary Emergency and Critical Care·Alex M LynchCarolina Riccó
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Marjory B Brooks, James L Catalfamo
Oct 4, 2012·Topics in Companion Animal Medicine·Stephanie Ann Smith
May 1, 2007·The Veterinary Clinics of North America. Small Animal Practice·Kari V Lunsford, Andrew J Mackin
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Robert GoggsDaniel L Chan
Feb 9, 2011·Veterinary Clinical Pathology·Virginie AllegretChristian Bédard
Aug 27, 2014·Journal of Veterinary Emergency and Critical Care·Alex M LynchClaire R Sharp
Mar 17, 2015·Journal of Veterinary Emergency and Critical Care·Cynthia M PanekDomenico Bianco
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Carrie KavanaghCynthia R L Webster
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Jul 6, 2014·Annals of Occupational and Environmental Medicine·June T SpectorMargaret Hughes
Nov 6, 2009·Journal of the American Animal Hospital Association·Kari V LunsfordMarjory Brooks
Jun 28, 2016·American Journal of Veterinary Research·Jette C Schönig, Reinhard H Mischke
Apr 22, 2017·Veterinary Clinical Pathology·Carolyn Gara-BoivinChristian Bédard
Jun 13, 2017·Veterinary Clinical Pathology·Carolyn Gara-BoivinChristian Bédard

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