Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
S C M BarbosaR C P Lima-Júnior

Abstract

Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy and chemotherapy-associated xerostomia. This study investigated the protective effect of amifostine on an experimental model of OM. Hamsters were divided into six groups: saline control group (5 mL/kg), mechanical trauma (scratches) of the right cheek pouch; 5-FU (60 and 40 mg/kg, ip, respectively, administered on days 1 and 2); amifostine (12.5, 25, or 50 mg/kg) + 5-FU + scratches. Salivation rate was assessed and the animals were euthanized on day 10 for the analysis of macroscopic and microscopic injury by scores. Tissue samples were harvested for the measurement of neutrophil infiltration and detection of inflammatory markers by ELISA and immunohistochemistry. 5-FU induced pronounced hyposalivation, which was prevented by amifostine (P<0.05). In addition, 5-FU injection caused pronounced tissue injury accompanied by increased neutrophil accumulation, tumor...Continue Reading

References

Apr 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·S T SonisD Florine
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Mar 28, 2002·Seminars in Radiation Oncology·Jens BüntzelDietmar Fröhlich
Apr 27, 2004·Cancer·Edward B RubensteinUNKNOWN International Society for Oral Oncology
Apr 6, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rene-Jean BensadounDorothy Keefe
May 19, 2006·Cancer Chemotherapy and Pharmacology·C K L P BatistaR A Ribeiro
Sep 1, 2006·Cancer Chemotherapy and Pharmacology·R F C LeitãoG A C Brito
Dec 13, 2006·Digestive Diseases and Sciences·José Maurício S C MotaMarcellus H L P de Souza
Jul 10, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D E PetersonUNKNOWN ESMO Guidelines Working Group
Sep 18, 2010·Oral Diseases·S T Sonis
Oct 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
May 31, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lauren J RadvanskyAsif Siddiqui
Mar 13, 2014·Cancer·Rajesh V LallaUNKNOWN Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Societ
Dec 17, 2014·Periodontology 2000·Andrea Monti-HughesMaria E Itoiz
Mar 31, 2015·Critical Reviews in Oncology/hematology·Aurora MirabileR Phillip Dellinger
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marwan G Fakih
Dec 24, 2015·The Cochrane Database of Systematic Reviews·Philip RileyMartin G McCabe
Apr 2, 2016·Journal of Clinical and Experimental Dentistry·Begonya Chaveli-López, José V Bagán-Sebastián
May 1, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Naoto OkadaKeisuke Ishizawa
Oct 28, 2016·Cancer Chemotherapy and Pharmacology·Ronaldo A RibeiroRoberto C P Lima-Júnior
Jun 24, 2017·Frontiers in Pharmacology·Marika CinauseroStephen T Sonis
Oct 24, 2017·PloS One·Susana Barbosa RibeiroCaroline Addison Carvalho Xavier de Medeiros
May 20, 2018·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S BockelC Chargari

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Citations

Sep 24, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A F PereiraM L Vale
Apr 16, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yuan ZhouHaozhen Ren
Jun 24, 2021·Chemical Senses·Anish A SarkarEugene R Delay
Aug 20, 2021·Amino Acids·Khetyma Moreira FonsecaJand Venes Rolim Medeiros

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Methods Mentioned

BETA
light microscopy

Software Mentioned

GraphPad Prism

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