PMID: 3757474Sep 1, 1986Paper

Amikacin, ethambutol, and rifampin for treatment of disseminated Mycobacterium avium-intracellulare infections in patients with acquired immune deficiency syndrome

Diagnostic Microbiology and Infectious Disease
E J Baron, L S Young

Abstract

Synergistic combinations of achievable serum levels of amikacin, rifampin, and ethambutol were tested for their ability to inhibit growth of Mycobacterium avium-intracellulare strains isolated from seven patients with acquired immune deficiency syndrome. Even when the isolates were very resistant to the individual antimicrobial agents in vitro, growth was completely inhibited by all combinations of the three agents tested. Four of the patients treated with a combined regimen of amikacin, rifampin, and ethambutol showed clinical improvement. Synergistic antimicrobial susceptibility tests seem to more accurately represent the efficacy of combined regimens used to treat these extremely resistant mycobacteria than do conventional susceptibility determinations with individual antimicrobial agents.

Citations

Jan 1, 1994·International Journal of Antimicrobial Agents·V S Georgiev
Jul 1, 1994·Seminars in Roentgenology·J E Kuhlman
May 9, 1991·The New England Journal of Medicine·C R Horsburgh
Jun 2, 1988·The New England Journal of Medicine·A E GlattS H Landesman
Aug 1, 1996·Antimicrobial Agents and Chemotherapy·L Heifets
Jul 23, 2021·Expert Opinion on Pharmacotherapy·Jelmer RaaijmakersJakko van Ingen

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