Abstract
The number of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin outpatient parenteral antibiotic therapy (OPAT) for UTIs caused by ESBL-EC in patients not pre-treated with carbapenem. We retrospectively evaluated the outcomes of amikacin OPAT for UTIs caused by ESBL-EC. From November 2011 to October 2012, eight females, who could not be hospitalized for carbapenem treatment, were treated with amikacin OPAT for nine episodes of non-bacteremic ESBL-EC UTIs. Seven of the eight patients had one or more comorbidities. Of the nine UTI cases, three had symptomatic lower UTIs and six had non-bacteremic upper UTIs. In all of the cases, symptomatic and laboratory improvements were observed following amikacin OPAT. One patient showed a delayed relapse with bilateral microabscesses 3 weeks after treatment cessation; however, a clinical and microbiological cure was eventually reached. All of the patients were able to tolerate amikacin OPAT without any significant nephrotoxicity or ototoxicity. Amikacin OPAT represents a feasible ther...Continue Reading
References
Nov 22, 2008·The Journal of Antimicrobial Chemotherapy·Leonard LeiboviciMical Paul
May 13, 2010·The Journal of Antimicrobial Chemotherapy·Rohit BazazTrevor G Winstanley
Dec 15, 2010·Critical Care Clinics·William A Craig
Jul 20, 2011·Diagnostic Microbiology and Infectious Disease·Daryl J HobanRobert Badal
Aug 31, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Sun Hee ParkJin-Hong Yoo
Nov 8, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesús Rodríguez-BañoUNKNOWN Extended-Spectrum Beta-Lactamases–Red Española de Investigación en Patología Infecciosa/Grupo de Estudio de Infección Hospit
Jul 4, 2012·International Journal of Antimicrobial Agents·Po-Liang LuPo-Ren Hsueh
Aug 24, 2012·The Journal of Antimicrobial Chemotherapy·Konstantinos Z VardakasMatthew E Falagas
Oct 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nan-Yao LeeWen-Chien Ko
Nov 15, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yohei DoiDavid L Paterson
Dec 29, 2012·Scandinavian Journal of Infectious Diseases·Håkan HanbergerUNKNOWN Swedish Reference Group for Antibiotics
Apr 30, 2013·Clinical Therapeutics·Sam K BouchillonStephen P Hawser
Jun 15, 2014·The Journal of Antimicrobial Chemotherapy·Sun Hee ParkJin-Hong Yoo
Sep 3, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tumay IpekciOrcun Celik
Citations
Aug 11, 2016·Journal of Medicinal Chemistry·Ido M HerzogMicha Fridman
Jul 28, 2017·Journal of Medical Microbiology·Takae ShimizuYoshiaki Hikasa
May 17, 2018·PloS One·Pavankumar RudrabhatlaTamilarasu Kadhiravan
Apr 6, 2018·The Tohoku Journal of Experimental Medicine·Emilija NikolićMaya Rubtsova
Mar 24, 2018·Paediatric Drugs·Saeed AlqahtaniWael Mansy
Aug 4, 2019·Southern Medical Journal·C Whitney WhiteJacob Campbell
Jul 10, 2018·The Journal of Antimicrobial Chemotherapy·Marianne BollestadUNKNOWN (the Norwegian ESBL UTI study group)
Jul 22, 2018·Diseases·Karikari Asafo-AdjeiEric S Donkor
Sep 20, 2018·F1000Research·Zoi Dorothea Pana, Theoklis Zaoutis
Apr 11, 2018·Infection & chemotherapy·Cheol In KangSeong Heon Wie
Nov 14, 2019·Expert Review of Anti-infective Therapy·Abdullah Tarık Aslan, Murat Akova
May 5, 2021·Investigative and Clinical Urology·Sun Tae AhnMi Mi Oh
Apr 20, 2021·The Pediatric Infectious Disease Journal·Gavriel HainShalom Ben-Shimol
Aug 18, 2021·BMC Infectious Diseases·Carrie P WongMariana Abraham