Amikacin therapy for urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli

The Korean Journal of Internal Medicine
Sung-Yeon ChoJin-Hong Yoo

Abstract

The number of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin outpatient parenteral antibiotic therapy (OPAT) for UTIs caused by ESBL-EC in patients not pre-treated with carbapenem. We retrospectively evaluated the outcomes of amikacin OPAT for UTIs caused by ESBL-EC. From November 2011 to October 2012, eight females, who could not be hospitalized for carbapenem treatment, were treated with amikacin OPAT for nine episodes of non-bacteremic ESBL-EC UTIs. Seven of the eight patients had one or more comorbidities. Of the nine UTI cases, three had symptomatic lower UTIs and six had non-bacteremic upper UTIs. In all of the cases, symptomatic and laboratory improvements were observed following amikacin OPAT. One patient showed a delayed relapse with bilateral microabscesses 3 weeks after treatment cessation; however, a clinical and microbiological cure was eventually reached. All of the patients were able to tolerate amikacin OPAT without any significant nephrotoxicity or ototoxicity. Amikacin OPAT represents a feasible ther...Continue Reading

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Citations

Nov 14, 2019·Expert Review of Anti-infective Therapy·Abdullah Tarık Aslan, Murat Akova

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