PMID: 428822Feb 1, 1979Paper

Amino acid and peptide absorption after proximal small intestinal resection in the rat

Gut
A B GarridoY S Kim

Abstract

In experimental animals with massive proximal intestinal resection, in vivo ileal absorption of an amino acid mixture containing L-leucine and glycine as well as two different dipeptides, L-leucyl-glycine and glycyl-L-leucine, were compared. Both amino acid and dipeptide absorption were markedly enhanced in the ileal segments. However, the absorption rates from the two perfused dipeptides differed. L-leucine absorption from L-leucyl-glycine was much greater than from glycyl-L-leucine. Brush border amino-peptidase activities after resection were also increased but dissociation between absorption and hydrolytic activity occurred. This study indicates that certain dipeptides are handled differently by adapting ileal segments. Furthermore, the changes observed probably reflect mucosal cellular hyperplasia occurring in association with intestinal adaptation.

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Citations

Feb 1, 1981·Digestive Diseases and Sciences·A B GarridoY S Kim
Sep 1, 1984·Digestive Diseases and Sciences·K J CurtisY S Kim
Sep 1, 1982·Digestive Diseases and Sciences·D L Antonson, J A Vanderhoof
Jan 1, 1990·The International Journal of Biochemistry·J M Argiles, F J Lopez-Soriano
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·F MurilloJ Bolufer
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J W RobinsonH Menge
Mar 21, 2007·Digestive Diseases and Sciences·Genia RadevaRobert Farinotti
Oct 24, 1985·Biochimica Et Biophysica Acta·J BoluferM L Murillo
Jul 5, 2006·Journal of Pediatric Surgery·James M KielyDeborah A Swartz-Basile
Oct 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Siamak A Adibi
Apr 9, 2013·Bioscience, Biotechnology, and Biochemistry·Kayoko EsakiShigeki Furuya

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