Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101

Journal of Natural Products
Minghe LuoJianhua Ju

Abstract

Emodacidamides A-H (1-8), natural products featuring anthraquinone-amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities. Emodacidamides A (1), C (3), D (4), and E (5) inhibited interleukin-2 secretion from Jurkat cells with IC50 values of 4.1, 5.1, 12, and 5.4 μM, respectively.

References

Jan 24, 2006·Journal of Industrial Microbiology & Biotechnology·Punyasloke BhaduryPhillip C Wright
Jun 19, 2012·Journal of Natural Products·Hongbo HuangJianhua Ju
Mar 22, 2014·Natural Product Reports·Antonio EvidenteRobert Kiss
Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
Apr 14, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Shih-Chang ChienWen-Chin Yang

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Citations

Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cong WangShugeng Cao
Feb 10, 2021·Marine Drugs·Anton N YurchenkoEkaterina A Yurchenko
Jan 1, 2019·Journal of Natural Products·Klaus WolkensteinChristian Griesinger
Mar 3, 2020·Journal of Natural Products·Meng-Hua WangZhong-Mei Zou

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