Abstract
Interferons (IFNs) are commonly grouped into type I and type II IFN. Type I IFNs are known as antiviral IFNs including IFN-α, IFN-β, and IFN-ω whereas type II IFN is referred to immune IFN and IFN-γ is only member of the type II IFN. Type I IFNs are induced by virus invading however type II IFN is produced by mitogenic or antigenic stimuli. IFN-τ was first identified in ruminant ungulates as a pregnancy recognition hormone, trophoblastin. IFN-τ constitutes a new class of type I IFN, which possesses the common features of type I IFN, such as the ability to prevent viral infection and to limit cell proliferation. In addition, IFN-τ is unique in that it is induced by pregnancy unlike other type I IFNs. We cloned Bos taurus (B. T.) Coreanae IFN-τ from peripheral blood mononuclear cells. The amino acid sequence of B. T. Coreanae IFN-τ shares only 90.3% identity with that of Holstein dairy cow. Recombinant B. T. Coreanae and Holstein IFN-τ proteins were expressed in Escherichia coli and the antiviral activity of IFN-τ proteins were examined. Both recombinant proteins were active and protected human WISH and bovine MDBK cells from the cytopathic effect of vesicular stomatitis virus. The recombinant IFN-τ protein of B. T. Coreanae and ...Continue Reading
References
Sep 14, 1990·Journal of Immunological Methods·Y Aida, M J Pabst
Apr 29, 1988·Biochemical and Biophysical Research Communications·C H PontzerH M Johnson
Sep 1, 1995·Biology of Reproduction·T E SpencerF W Bazer
May 6, 1994·Cell·D NovickM Rubinstein
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·P S SubramaniamH M Johnson
Jun 13, 1997·The Journal of Biological Chemistry·A GhoshG C Sen
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·F W BazerT L Ott
Jan 31, 1998·The Journal of Biological Chemistry·A GhoshG C Sen
Dec 17, 1998·The Journal of Endocrinology·R S RobinsonD C Wathes
Jan 9, 1999·The Journal of Biological Chemistry·S N SarkarG C Sen
Apr 14, 1999·Trends in Cell Biology·A M van der Bliek
May 20, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D Rebouillat, A G Hovanessian
Aug 28, 1999·The Journal of Biological Chemistry·S N SarkarG C Sen
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K E MogensenG Uzé
Sep 7, 2001·Cytokine & Growth Factor Reviews·K OritaniY Matsuzawa
Oct 28, 2005·Biology of Reproduction·C Allison GrayThomas E Spencer
Feb 14, 2006·Endocrinology·Yizhen ChenR Michael Roberts
Aug 1, 1997·Theriogenology·K E WolfsdorfW W Thatcher
Jun 28, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Caralee SchaeferRichard N Harkins
Jul 31, 2007·Cytokine & Growth Factor Reviews·R Michael Roberts