Amino acid handling in uremic rats: citrulline, a reliable marker of renal insufficiency and proximal tubular dysfunction

Metabolism: Clinical and Experimental
O LevillainC Hassler

Abstract

The kidney is involved in amino acid reabsorption and metabolism; consequently, in renal insufficiency, these important functions are disturbed, as has been reported in animals and patients. In a first experimental series, rats were subjected to degrees of nephrectomy (NX) varying between 10% and 90%. Three weeks later, amino acid levels were measured in plasma to correlate the levels with the degree of NX. The results indicate that in the range of 33% to 74% NX, the plasma concentration of only three to four amino acids was modified, whereas in rats with 84% NX, the concentration of 11 amino acids was disturbed, compared with sham-operated rats. Citrullinemia was enhanced in uremic rats and correlated with the degree of NX. More interestingly, citrullinemia was increased in the range of 10% to 33% NX without any changes in uremia and creatininemia, two well-known markers of uremic states. A second experimental series was designed to study the time course of changes in aminoacidemia to find a marker for the onset of renal failure. Rats were subjected to 36% NX for a period of 1 to 21 days. Uremia and creatininemia peaked 24 to 48 hours after NX, and creatinine clearance (Clcreat) concomitantly diminished. Unfortunately, these t...Continue Reading

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Citations

Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cécile Héliès-ToussaintAlain Grynberg
May 22, 2007·The Journal of Nutrition·Christophe Moinard, Luc Cynober
Jul 25, 2014·American Journal of Physiology. Renal Physiology·Juan C MariniMarta L Fiorotto
Sep 29, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carole RougéDominique Darmaun
Aug 6, 2005·Amino Acids·E CurisL Cynober
Mar 27, 2009·Biopharmaceutics & Drug Disposition·Keisuke MitsuokaIkumi Tamai
Jan 21, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alexis PooleMarianne Chapman
Apr 14, 2016·European Journal of Clinical Pharmacology·Kim VanstraelenIsabel Spriet
Jul 22, 2018·Nutrients·Timothy D AllertonBrian A Irving
May 22, 2019·Applied Biochemistry and Biotechnology·Zuleen Delina Fasya Abdul GhaniZamri Chik
May 1, 2009·American Journal of Physiology. Renal Physiology·Masanori NakakariyaIkumi Tamai
Feb 24, 2015·Nutrients·Karolina A P WijnandsMartijn Poeze
Sep 7, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·François MifsudUNKNOWN Bariasperm Study Group
Aug 27, 2021·Toxins·Jesús Iván Lara-PradoAlejandro Treviño-Becerra

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