PMID: 2106267Feb 1, 1990Paper

Amino acid metabolism after intense exercise

The American Journal of Physiology
J T DevlinD Bier

Abstract

We studied postexercise amino acid metabolism, in the whole body and across the forearm. Seven volunteers were infused with L-[alpha-15N]lysine and L-[1-13C]-leucine twice [one time during 3 h after cycle exercise (75% VO2max), and one time in the resting state]. Whole body protein breakdown was estimated from dilution of L-[alpha-15N]lysine and L-[1-13C]ketoisocaproic acid (KIC) enrichments in plasma. Leucine oxidation was calculated from 13CO2 enrichments in expired air. Whole body protein breakdown was not increased above resting levels during the recovery period. Leucine oxidation was decreased after exercise (postexercise 13 +/- 2.3 vs. resting 19 +/- 3.2 mumol.kg-1.h-1; P less than 0.02), while nonoxidative leucine disposal was increased (115 +/- 6.1 vs. 103 +/- 5.6 micrograms.kg-1.min-1; P less than 0.02). After exercise, forearm net lysine balance was unchanged (87 +/- 25 vs. 93 +/- 28 nmol.100 ml-1.min-1), but there were decreases in forearm muscle protein degradation (219 +/- 51 vs. 356 +/- 85 nmol.100 ml-1.min-1; P less than 0.05) and synthesis (132 +/- 41 vs. 255 +/- 69 nmol.100 ml-1.min-1; P less than 0.01). In conclusion, after exercise 1) whole body protein degradation is not increased, 2) leucine disposal is dir...Continue Reading

Citations

Dec 14, 2007·American Journal of Physiology. Cell Physiology·Hélène Richard-BulteauNathalie Koulmann
Aug 19, 2007·Journal of Applied Physiology·Gregory C HendersonGeorge A Brooks
Jan 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew P HarberScott W Trappe
Jun 16, 2001·Journal of Applied Physiology·L S LamontS C Kalhan
May 26, 2005·American Journal of Physiology. Endocrinology and Metabolism·Douglas R BolsterNancy R Rodriguez
Feb 20, 2019·American Journal of Physiology. Endocrinology and Metabolism·Arash BandeganPeter W R Lemon
Oct 21, 2020·Advances in Nutrition·Katrina L HindeSophie L Wardle
Jun 3, 2021·International Journal of Environmental Research and Public Health·Abdullah F AlghannamMaha H Alhussain

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