Amino acid mutations in Ebola virus glycoprotein of the 2014 epidemic

Journal of Medical Virology
Marta GiovanettiMassimo Ciccozzi

Abstract

Zaire Ebola virus (EBOV) is an enveloped non-segmented negative strand RNA virus of 19 kb in length belonging to the family Filoviridae. The virus was isolated and identified in 1976 during the epidemic of hemorrhagic fever in Zaire. The most recent outbreak of EBOV among humans, was that occurred in the forested areas of south eastern Guinea, that began in February 2014 and is still ongoing. The recent Ebola outbreak, is affecting other countries in West Africa, in addiction to Guinea: Liberia, Nigeria, and Sierra Leone. In this article, a selective pressure analysis and homology modeling based on the G Glycoprotein (GP) sequences retrieved from public databases were used to investigate the genetic diversity and modification of antibody response in the recent outbreak of Ebola Virus. Structural and the evolutionary analysis underline the 2014 epidemic virus being under negative selective pressure does not change with respect to the old epidemic in terms of genome adaptation.

References

Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Jul 27, 2001·Molecular Biology and Evolution·M AnisimovaZ Yang
May 29, 2002·Molecular Biology and Evolution·Maria AnisimovaZiheng Yang
Feb 4, 2005·Molecular Biology and Evolution·Ziheng YangRasmus Nielsen
Feb 11, 2005·Molecular Biology and Evolution·Sergei L Kosakovsky Pond, Simon D W Frost
Jul 9, 2005·Microbes and Infection·Xavier PourrutEric Maurice Leroy
Aug 19, 2005·Molecular Biology and Evolution·Sergei Kosakovsky Pond, Spencer V Muse
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tatiana J WittmannEric M Leroy
Nov 20, 2009·Acta Crystallographica. Section D, Biological Crystallography·Jeffrey E LeeErica Ollmann Saphire
Apr 21, 2011·Bioinformatics·Joost Van DurmeFrederic Rousseau
Oct 30, 2012·Molecular Immunology·Alba GrifoniMassimo Amicosante
Nov 6, 2012·Annual Review of Pathology·Slobodan Paessler, David H Walker
Aug 2, 2013·The New England Journal of Medicine·Ariel SobarzoLeslie Lobel
Aug 29, 2013·BioMed Research International·Alba GrifoniMassimo Amicosante
Jul 6, 2014·Frontiers in Microbiology·Robert V Stahelin

❮ Previous
Next ❯

Citations

Jan 23, 2016·Advances in Bioinformatics·Vladislav Victorovich KhrustalevTatyana Aleksandrovna Khrustaleva
Apr 18, 2016·Asian Pacific Journal of Tropical Medicine·Alba GrifoniMassimo Ciccozzi
Jun 28, 2019·Journal of Medical Virology·Massimo CiccozziSilvia Angeletti
Sep 25, 2019·International Journal of Molecular Sciences·Madiiha Bibi MandaryChit Laa Poh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Related Papers

Nursing Standard
MMWR. Morbidity and Mortality Weekly Report
Incident Management System Ebola Epidemiology Team, CDCCenters for Disease Control and Prevention (CDC)
© 2021 Meta ULC. All rights reserved