PMID: 12771361May 29, 2003Paper

Amino acid pharmacokinetics and safety assessment

The Journal of Nutrition
Dennis M Bier

Abstract

Tracer kinetic studies of amino acid metabolism during periods of high amino acid intake should allow insights into adaptive or maladaptive regulatory mechanisms controlling amino acid catabolic or disposal events before clinically evident effects. The principles of amino acid tracer kinetics have been well defined, but their application to establishing upper safe intake levels has been essentially nonexistent. Similarly, the pharmacology field has well-established disciplines of toxicokinetics (the relationship of toxicant dose and delivery to its site of action) and toxicodynamics (the relationship of toxicant at its site of action and downstream functional consequences), but these principles have not been transferred to the field of amino acid metabolism. In this context, a theoretical framework is presented for tracer kinetic experiments to help establish upper tolerable levels of amino acid infusion and/or ingestion. In addition, experiments to couple specific amino acid intake levels with their consequent physiological dynamic effects are suggested to lead to the construction of benefit-risk curves that may permit definition of safe amino acid intake ranges for the population.

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Citations

Dec 4, 2003·The Journal of Nutrition·Konrad DabrowskiJacques Rinchard
May 17, 2006·The Journal of Nutrition·Luc Cynober
May 25, 2007·Food and Nutrition Bulletin·Peter J Aggett
Jan 23, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Sascha VerbruggenLeticia Castillo
Oct 5, 2010·Nutrition Reviews·François MariottiIrène Margaritis
May 17, 2006·The Journal of Nutrition·Sakino ToueRyosei Sakai
Jun 3, 2004·The Journal of Nutrition·Ryosei SakaiTakeshi Kimura
Feb 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A CaimariA Palou

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