Amino acid sensing and mTOR regulation: inside or out?

Biochemical Society Transactions
Deborah C I GoberdhanC A Richard Boyd

Abstract

mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signalling on a number of major human diseases and has helped to drive research to understand how TOR (target of rapamycin) is itself regulated. While it is clear that amino acids can affect TOR signalling, how these molecules are sensed by TOR remains controversial, perhaps because cells use different mechanisms as environmental conditions change. Even the question of whether they have an effect inside the cell or at its surface remains unresolved. The present review summarizes current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change.

References

Mar 29, 2001·The Journal of Biological Chemistry·R RussnakS L McIntire
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C SagnéB Giros
Oct 30, 2001·Current Genetics·H Forsberg, P O Ljungdahl
Apr 18, 2002·The Journal of Biological Chemistry·Michael BollHannelore Daniel
Sep 25, 2003·Cell·Julien ColombaniPierre Léopold
Jan 14, 2004·The Journal of Biological Chemistry·Marjon van SlegtenhorstElizabeth Petri Henske
Apr 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·John R Bermingham, Jamie Pennington
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld
Oct 7, 2004·Nature Cell Biology·Estela JacintoMichael N Hall
Oct 29, 2004·Journal of Cell Science·D Grahame Hardie
Jul 29, 2005·The Journal of Biological Chemistry·Maya P ByfieldJonathan M Backer
Sep 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Takahiro NobukuniGeorge Thomas
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Apr 25, 2006·Biochemical and Biophysical Research Communications·Claudia BuergerVuk Stambolic
May 3, 2006·The Journal of Cell Biology·Boqian WuMorten C Kielland-Brandt
Jun 21, 2006·The Journal of Cell Biology·Krista M HennigThomas P Neufeld
Aug 18, 2006·Nature Reviews. Cancer·David M Sabatini
Oct 17, 2006·Oncogene·J B Easton, P J Houghton
Nov 25, 2006·Biochimica Et Biophysica Acta·David T Thwaites, Catriona M H Anderson
Jan 12, 2007·Molecular Biology of the Cell·Xiangyu Liu, X F Steven Zheng
Jan 27, 2007·The Biochemical Journal·Greg M FindlayRichard F Lamb
Apr 11, 2007·Developmental Cell·Prashanth T Bhaskar, Nissim Hay
Oct 12, 2007·Biochimie·Sophie PattingrePatrice Codogno
Oct 25, 2007·Biochemical Society Transactions·B ReynoldsD C I Goberdhan
Oct 25, 2007·Biochemical Society Transactions·S R Kimball
Nov 13, 2007·Biochimica Et Biophysica Acta·Romina MaroneMatthias P Wymann
Jan 2, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jaclyn LoPiccoloPhillip A Dennis
May 10, 2008·The Biochemical Journal·David A Fruman, Aimee L Edinger
May 14, 2008·The Journal of Cell Biology·Gábor JuhászThomas P Neufeld
May 24, 2008·Science·Yasemin SancakDavid M Sabatini
Jul 8, 2008·Nature Cell Biology·Eunjung KimKun-Liang Guan
Sep 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Joseph AvruchNing Dai
Sep 23, 2008·Developmental Cell·Francesco Cecconi, Beth Levine

❮ Previous
Next ❯

Citations

May 11, 2012·Inflammatory Bowel Diseases·Rachel Marion-LetellierSubrata Ghosh
Sep 21, 2010·Cancer Chemotherapy and Pharmacology·Christina Trojel-HansenSøren Jensby Nielsen
Mar 23, 2010·American Journal of Physiology. Endocrinology and Metabolism·Micah J DrummondBlake B Rasmussen
Nov 8, 2011·Journal of Molecular Evolution·Teunis J P van DamBerend Snel
Oct 8, 2013·The Journal of Nutrition, Health & Aging·E A OffordJ M Penninger
Feb 19, 2011·Mathematical Biosciences·Jay E Mittenthal, Lihua Zou
Jan 4, 2012·Cellular Microbiology·Debasish GhoshAnthony P Sinai
Jul 28, 2011·Medicinal Research Reviews·Jonathan McConathyMark M Goodman
Sep 14, 2010·Current Opinion in Immunology·Christian PeterStephen P Cobbold
Apr 29, 2014·Frontiers in Genetics·Noha Ahmed NasefLynnette R Ferguson
Nov 23, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Erich Roth, Wilfred Druml
Jan 19, 2019·Molecular Genetics and Genomics : MGG·Muhammad-Kashif ZahoorJacques Montagne
Nov 4, 2010·American Journal of Physiology. Endocrinology and Metabolism·Søren ReitelsederLars Holm
Jan 16, 2009·Biochemical Society Transactions·Deborah C I Goberdhan, C A Richard Boyd
Jul 5, 2018·Frontiers in Pharmacology·Shih-Jung Fan, Deborah C I Goberdhan
Nov 2, 2012·International Journal of Food Sciences and Nutrition·Angelos K Sikalidis
Jun 18, 2021·Frontiers in Cell and Developmental Biology·James P White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.