PMID: 386347Aug 1, 1979Paper

Amino acid sequence and physicochemical similarities between streptococcal M protein and mammalian tropomyosin

Proceedings of the National Academy of Sciences of the United States of America
B HoseinV A Fischetti

Abstract

The amino-terminal sequences of two peptides of type 24 streptococcal M protein show similarities with that of rabbit skeletal muscle tropomyosin, having up to 40% identical residues and probabilities of occurring by chance as low as P less than 10(-5). In addition, a hexapeptide (Glu-Ala-Glu-Lys-Ala-Ala) that is found five times in the M24 protein was shown to be identical to a sequence in tropomyosin. Similarities are also seen in the amino acid compositions and physicochemical properties of the two proteins. The amino-terminal sequences of peptides from another bacterial surface protein, staphylococcal protein A, are highly correlated with segments of two other myofibrillar proteins, rabbit actin (P less than 10(-7)) and rabbit myosin A1 light chain (P less than 10(-6)). The data presented suggest that a close structural relationship exists between mammalian muscle proteins and the biologically active surface proteins of staphylococci and streptococci. In addition, the correlation between sequences in M protein and tropomyosin represents direct evidence of a structural similarity at a molecular level between a streptococcal protein and a mammalian muscle component and may therefore prove relevant to the pathogenicity of the ...Continue Reading

References

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Citations

Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G N PhillipsV A Fischetti
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B N ManjulaV A Fischetti
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W DunneK A Joiner
Jun 1, 1985·The Journal of Experimental Medicine·V A FischettiJ R Scott
Jun 9, 2005·The Journal of Experimental Medicine·Emil C Gotschlich, Vincent A Fischetti
Mar 4, 2014·Indian Heart Journal·Rajendra Tandon
Oct 30, 1986·Biochemical and Biophysical Research Communications·B N Manjula, V A Fischetti
Feb 15, 1986·Archives of Biochemistry and Biophysics·J M Chalovich, V A Fischetti
Aug 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chelsea M StewartPartho Ghosh
Jul 1, 1982·Angiology·S DeCarvalho
Nov 1, 1979·Hospital Practice·E H BeacheyA L Bisno
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Nov 1, 1985·Infection and Immunity·R S BerkL Hazlett

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