PMID: 708376Sep 1, 1978Paper

Amino acid sequence of the N-terminal 108 amino acid residues of the B chain of subcomponent C1q of the first component of human complement

The Biochemical Journal
K B Reid, E O Thompson

Abstract

The amino acid sequence of the N-terminal 108 residues of the B chain of subcomponent C1q of the first component of human complement was determined. The B chain has a blocked N-terminal amino acid, which was judged to be 5-oxopyrrolidine-2-carboxylic acid. A collagen-like region of 84 residues was found, which started at position B-6, and all of the six hydroxylysine residues and 12 hydroxyproline residues present in the chain were found in this region. Four of the six hydroxylysine residues may be glycosylated. The repeating nature of the collagen-like region is broken at position B-9, where alanine is found in a position where glycine would be expected. The exact position of the interchain disulphide bond joining the A and B chains of human subcomponent C1q was shown to be between residues A4 and B4.

Citations

May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Isabelle BallyN M Thielens
Nov 28, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R R Porter
Oct 26, 1978·Nature·R R Porter, K B Reid
Oct 1, 1985·Bioscience Reports·R F Doolittle
Feb 1, 1983·European Journal of Immunology·H S SlayterL A Steiner

Related Concepts

Complement component C1
Disulfides

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