Amino acid sequences of pilins from serologically distinct strains of Bacteroides nodosus

Journal of Protein Chemistry
N M McKernP M Strike

Abstract

Amino acid sequences of pilin from a strain of Bacteroides nodosus from serogroup B (234) and serogroup C (217) were determined. The amino-terminal N-methylphenlalanine residue of both proteins was followed by a hydrophobic sequence of 30 residues closely related to the N-terminal sequence of other pili having an amino-terminal residue of N-methylphenylalanine. These data lend support to the hypothesis that in pilins of this type, the amino-terminal sequence functions as a transport signal necessary for pilin to reach its external environment, as well as promoting intersubunit interactions for maintenance of the structural integrity of the pilus. Two hydrophilic hypervariable regions can be discerned across the pilin sequences, indicating possible locations of antigenic domains.

References

Jan 1, 1977·Methods in Enzymology·P Bornstein, G Balian
Jul 1, 1985·Journal of Bacteriology·C F MarrsS Falkow
Jul 1, 1986·Journal of Bacteriology·T C EllemanD J Stewart
Apr 1, 1973·Australian Journal of Biological Sciences·I J O'Donnell
Jan 1, 1973·Journal of Comparative Pathology·J R Egerton
Jan 24, 1983·FEBS Letters·P A SastryW Paranchych
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T P Hopp, K R Woods
Jan 1, 1983·Methods in Enzymology·A S Inglis
Nov 1, 1983·Australian Veterinary Journal·P D ClaxtonJ R Egerton
Feb 1, 1982·European Journal of Biochemistry·J WilliamsK A Kuhn

Related Concepts

Outer Membrane Lipoproteins, Bacterial
Bacteroides
Bacterial Pilus
Sex Pili Structural Proteins

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