Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

Journal of Virology
Eefje J A SchrauwenRon A M Fouchier

Abstract

Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for α2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission.

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Citations

Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Aug 8, 2017·International Journal of Molecular Sciences·Wenhan ShaoJi-Long Chen
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tokiko WatanabeYoshihiro Kawaoka
Nov 11, 2019·Pathogens·Sara Hussein MahmoudMohamed Ahmed Ali
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Mar 25, 2020·Cold Spring Harbor Perspectives in Medicine·Chengjun Li, Hualan Chen
Oct 9, 2020·Cell Host & Microbe·Sander HerfstRon A M Fouchier

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