Amino acid transport in human and in sheep erythrocytes

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J D YoungJ C Ellory

Abstract

Amino acid transport was compared in human and in sheep erythrocytes. Kinetic studies established that human cells have three discrete amino acid transport systems, designated L, Ly+ and ASC. The L system is partially stereospecific, with a preference for large neutral amino acids. L-leucine has a threefold lower apparent Km and a twofold smaller Vmax than D-leucine. Alanine, cysteine and possibly dibasic amino acids are transported by this route, but with a low affinity. The Ly+ system is highly stereoselective, and specific for dibasic amino acids, including arginine. The ASC system is Na-dependent and selective for neutral amino acids of intermediate size. It has a particularly low apparent Km for cysteine and is stereospecific. Sheep erythrocytes lack these systems. Instead they possess an additional system (C system) responsible for the transport both of neutral and of dibasic amino acids, with cysteine as the optimal substrate. Although the substrate specificities of the human ASC and sheep C systems are similar, the sheep system does not require Na and has considerably higher apparent Km values. Dibasic amino acid transport (of lysine, but not of arginine) by the C system occurs with a low affinity.

Citations

Aug 1, 1982·Biochemical Genetics·J D YoungL Kilgour
Sep 1, 1990·The Journal of Membrane Biology·R Joshi, C M Gupta
Jan 1, 1981·The Journal of Membrane Biology·R Rosenberg
Jan 1, 1986·The Journal of Membrane Biology·S Bannai, N Tateishi
Nov 1, 1992·The International Journal of Biochemistry·C PicóA Palou
Apr 1, 1984·Molecular and Biochemical Parasitology·S P FrickerR A Klein
Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·J Lerner
Mar 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·C PicóA Palou
Aug 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·G Tunnicliff
Oct 17, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E OgawaN S Agar
Aug 30, 1988·Biochemical and Biophysical Research Communications·Y OhtsukaY Kawakami
Sep 9, 1985·Biochimica Et Biophysica Acta·D L Yudilevich, J H Sweiry
Sep 3, 1984·Biochimica Et Biophysica Acta·S Bannai
Jun 12, 1986·Biochimica Et Biophysica Acta·E K Hoffmann
Dec 7, 1981·Biochimica Et Biophysica Acta·R Rosenberg
Mar 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·C PicoA Palou
Aug 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·C PicóA Palou
Jun 5, 2007·The International Journal of Biochemistry & Cell Biology·Julia E RaftosPhilip W Kuchel
Jan 22, 1982·Biochimica Et Biophysica Acta·E A Al-Saleh, K P Wheeler
Feb 27, 1980·Biochemical and Biophysical Research Communications·P K Lauf, B E Theg
Dec 1, 1990·Bioscience Reports·A FelipeX Remesar
Mar 23, 1983·Biochimica Et Biophysica Acta·H Ginsburg, M Krugliak
May 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·C LoguercioG Nardi
Jul 24, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Ashish SinhaAnurag Tewari
Nov 8, 1996·The Journal of Biological Chemistry·N Zerangue, M P Kavanaugh
Feb 5, 2003·Journal of Biomedical Science·Godfrey Tunnicliff
Feb 8, 2019·Scientific Reports·Eugeniy S ProtasovElena I Sinauridze
Jan 9, 2020·Nitric Oxide : Biology and Chemistry·Francesca LeoMiriam M Cortese-Krott
Jan 23, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Van Pham Thi Ha ToMatthew E Loewen

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