Amino Acid Transporter SLC6A14 (ATB0,+ ) - A Target in Combined Anti-cancer Therapy

Frontiers in Cell and Developmental Biology
Katarzyna A Nałecz

Abstract

Cancer cells are characterized by quick growth and proliferation, demanding constant supply of various nutrients. Several plasma membrane transporters delivering such compounds are upregulated in cancer. Solute carrier family 6 member 14 (SLC6A14), known as amino acid transporter B0,+ (ATB0,+) transports all amino acids with exception of the acidic ones: aspartate and glutamate. Its malfunctioning is correlated with several pathological states and it is upregulated in solid tumors. The high expression of SLC6A14 is prognostic and unfavorable in pancreatic cancer, while in breast cancer it is expressed in estrogen receptor positive cells. As many plasma membrane transporters it resides in endoplasmic reticulum (ER) membrane after translation before further trafficking through Golgi to the cell surface. Transporter exit from ER is strictly controlled. The proper folding of SLC6A14 was shown to be controlled from the cytoplasmic side by heat shock proteins, further exit from ER and formation of coatomer II (COPII) coated vesicles depends on specific interaction with COPII cargo-recognizing subunit SEC24C, phosphorylated by kinase AKT. Inhibition of heat shock proteins, known to be upregulated in cancer, directs SLC6A14 to degradat...Continue Reading

References

Feb 1, 1975·Biology of Reproduction·S Schlafke, A C Enders
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q R LiuN Nelson
Jun 29, 1992·FEBS Letters·Q R LiuN Nelson
Oct 25, 1991·Science·B J HoffmanM J Brownstein
Jul 16, 1990·Biochemical and Biophysical Research Communications·T YamamotoH Imura
Aug 20, 1990·FEBS Letters·H NelsonN Nelson
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Dec 1, 1993·Endocrinology·J C TinajeroM L Dufau
Jan 12, 1999·Archives of Biochemistry and Biophysics·W DaiH K Sarkar
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H WoloskerS H Snyder
Jun 17, 2000·Biochimica Et Biophysica Acta·J Kerner, C Hoppel
Apr 18, 2001·The Journal of Clinical Investigation·T HatanakaM E Ganapathy
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S UgawaS Shimada
Feb 16, 2002·Biochemical and Biophysical Research Communications·Takahiro HatanakaVadivel Ganapathy
Mar 8, 2002·Cellular Signalling·Karleen M Nicholson, Neil G Anderson
Jan 6, 2005·The Journal of Biological Chemistry·Hitomi TakanagaMatthias A Hediger
Feb 4, 2005·The Biochemical Journal·Sonja KowalczukStefan Bröer
May 21, 2005·Biochimica Et Biophysica Acta·Naren GuptaVadivel Ganapathy
May 27, 2005·Seminars in Cancer Biology·Bryan C Fuchs, Barrie P Bode
Jun 29, 2005·The Journal of Membrane Biology·M H KarakossianS Eskandari
Jul 20, 2005·Molecular Pharmaceutics·Blisse Jain-VakkalagaddaAshim K Mitra
Sep 20, 2005·Gynecologic Oncology·Naren GuptaVadivel Ganapathy
Sep 28, 2005·The Biochemical Journal·Angelika BröerStefan Bröer
Nov 17, 2005·Oncogene·Deborah A Altomare, Joseph R Testa
Dec 27, 2005·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·M E Ganapathy, V Ganapathy

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Citations

Mar 12, 2021·Frontiers in Cell and Developmental Biology·María Florencia Carusela, J Miguel Rubi
Apr 4, 2021·Pharmaceuticals·Tyler SniegowskiVadivel Ganapathy

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Methods Mentioned

BETA
glycosylation
amino
electrophoresis
xenografts
biopsies
xenograft
imaging techniques
laser capture microdissection
RNAseq
chips

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