Amino acid use by the gastrointestinal tract of sheep given lucerne forage

The American Journal of Physiology
J C MacRaeA G Calder

Abstract

Essential amino acid (EAA) utilization by gastrointestinal tract (GIT) tissues has been investigated in sheep given 800 and 1,200 g/day lucerne pellets. Animals prepared with indwelling catheters into the aorta and the portal drained viscera plus cannulas into the small intestine were infused with mixed U-13C-labeled amino acid or (1-13C]leucine tracers into the jugular vein or directly into the small intestine. GIT sequestration of EAA from arterial and luminal AA pools was determined from tracer and tracee arterioportal concentration differences at both levels of intake. Proportional tracer 13C-labeled EAA extraction of the arterial supply, on first pass across the GIT during jugular infusion, ranged from 0.063 for histidine to 0.126 for leucine. Recovery of intestinally infused tracer 13C-EAA at the portal vein ranged from 0.61 for histidine to 0.83 for valine. These data were independent of intake. Calculated rates of tracee sequestration by GIT tissues represented 0.45-0.65 of whole body EAA flux, except for histidine, for which the values were much lower (0.25-0.32). With the exception of phenylalanine, more than 0.8 of the EAA used by the GIT was extracted from circulating blood, thus calling into question the theory tha...Continue Reading

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Citations

Jul 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Cécile BosDouglas G Burrin
Mar 11, 2006·Journal of Dairy Science·H LapierreG E Lobley
Mar 20, 2010·Amino Acids·Zhao-Lai DaiWei-Yun Zhu
Dec 10, 2020·Journal of Animal Science and Biotechnology·Virginia L Pszczolkowski, Sebastian I Arriola Apelo

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