PMID: 9420056Jan 7, 1998Paper

Amino acid variation in the GyrA subunit of bacteria potentially associated with natural resistance to fluoroquinolone antibiotics

Antimicrobial Agents and Chemotherapy
B Waters, Julian Davies

Abstract

In studies of genetic diversity in natural microbial populations, we have analyzed nucleotide sequences in the quinolone resistance-determining region of the bacterial gyrA gene in ciprofloxacin-resistant and nonselected soil bacteria obtained from the environment. It is apparent that this sequence is highly variable, and resistance to fluoroquinolone antibiotics occurring in environmental populations of bacteria is due at least in part to natural sequence variation in this domain. We suggest that the development of new antimicrobial agents, including completely synthetic antimicrobials such as the fluoroquinolones, should incorporate the analysis of resistance mechanisms among microbes in natural environments; these studies could predict potential mechanisms of resistance to be encountered in subsequent clinical use of the agents and would guide chemical modification designed to evade resistance development.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A SuginoN R Cozzarelli
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M GellertJ I Tomizawa
May 11, 1992·Nucleic Acids Research·G J OlsenC R Woese
Aug 1, 1991·Antimicrobial Agents and Chemotherapy·H YoshidaS Nakamura
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·R J Reece, A Maxwell
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1988·Molecular & General Genetics : MGG·H YoshidaS Nakamura
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·H ItoS Nakamura
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·H E TakiffW R Jacobs
Feb 1, 1996·Antimicrobial Agents and Chemotherapy·J VilaM T De Anta
Apr 1, 1996·Antimicrobial Agents and Chemotherapy·D J GriggsL J Piddock
Oct 1, 1996·Antimicrobial Agents and Chemotherapy·X S PanL M Fisher
Jan 1, 1997·Antimicrobial Agents and Chemotherapy·Q C TruongN J Moreau
Jan 1, 1996·Annual Review of Genetics·W M Huang

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Citations

Apr 24, 2003·Antimicrobial Agents and Chemotherapy·F MasselotD Raoult
Oct 8, 2019·Annals of the New York Academy of Sciences·Jessica KobylkaKlaas M Pos
Sep 28, 1999·Nature·M A GilliverC A Hart
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·N A el AminB Wretlind
Feb 9, 2012·Environmental Science and Pollution Research International·Gareth LewisEuan Smith
Aug 5, 2008·Microbial Ecology·Mindy G Brown, David L Balkwill
Nov 11, 1999·Medicinal Research Reviews·L A MitscherD M Shankel
May 29, 2009·The Journal of Antimicrobial Chemotherapy·Iyad AlmahmoudMax Maurin
Jan 21, 2006·Science·Vanessa M D'CostaGerard D Wright
Mar 2, 2010·Nature Reviews. Microbiology·Heather K AllenJo Handelsman
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·M MaurinD Raoult
Sep 9, 2020·Applied Microbiology and Biotechnology·Li YiYang Wang
Aug 13, 2004·Environmental Microbiology·Christian S RiesenfeldJo Handelsman
Jun 21, 2007·Journal of Applied Microbiology·M D EnglenP J Fedorka-Cray
Feb 28, 2020·Experimental and Therapeutic Medicine·Yong-Qi GanBin Zhu
Jul 12, 2001·Research in Microbiology·V C Nwosu
May 2, 2000·Drug Discovery Today·J A HeinemannC F Amábile-Cuevas
Jul 16, 2008·International Journal of Antimicrobial Agents·Silpak BiswasJean-Marc Rolain
Dec 31, 2005·Environmental Science & Technology·C W KnappD W Graham

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