PMID: 19870982Mar 31, 1940Paper

AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA

The Journal of Experimental Medicine
G H Whipple, F S Robscheit-Robbins

Abstract

Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded. Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase hemoglobin output on the average 23 to 25 gm. above the control level. This reaction amounts to 25 to 30 per cent of the new hemoglobin produced by the feeding of 300 gm. liver daily for 2 weeks-a standard liver test. Alanine, valine, isoleucine, and arginine in the same dosage increase the hemoglobin output on the average 13 to 17 gm. per 2 weeks over the control level. Leucine, methionine, lysine, tryptophane, and tyrosine fall in a middle group with hemoglobin output of about 20 gm. Isovaleric acid, beta-hydroxybutyric acid, glutaric acid, and asparagine have shown positive effects and the butyrate is unusually potent for hemoglobin production (Table 2). The isomeric and dl-synthetic forms of the amino acids are as effectively utilized in this reaction as are the natural forms.

References

Oct 31, 1937·The Journal of Experimental Medicine·F S Robscheit-Robbins, G H Whipple
Apr 30, 1939·The Journal of Experimental Medicine·P F HahnG H Whipple

Citations

Mar 1, 1946·The American Journal of Digestive Diseases·M SAHYUN
May 1, 1942·The Journal of Experimental Medicine·F S Robscheit-Robbins, G H Whipple
Feb 1, 1969·Archives of Disease in Childhood·M KhalilM Hafez

Related Concepts

Alanine
Anemia
Arginine
Asparagine
Aspartic Acid
Cystine
Canis familiaris
Glycine
Hemoglobin
Histidine

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