Amino acids and peptides. XXXII: A bifunctional poly(ethylene glycol) hybrid of fibronectin-related peptides

Biochemical and Biophysical Research Communications
M MaedaT Mayumi

Abstract

An amino acid type poly(ethylene glycol) (aaPPEG) was prepared and its application to a drug carrier was examined. The peptides, Arg-Gly-Asp (RGD) and Glu-Ile-Leu-Asp-Val (EILDV) which were reported as active fragments of Fibronectin (a cell adhesion protein), were conjugated with aaPEG (molecular weight, 10,000). The hybrid, RGD-aaPEG-EILDV, was prepared by a combination of the solid-phase method and the solution method. Antiadhesive activity of the peptides was not lost by its hybrid formation with the large aaPEG molecule. A mixture of RGD (0.43 mmol) and EILDV (0.43 mmol) did not demonstrate an antiadhesive effect, but the hybrid containing 0.43 mmol of each peptide did exhibit this effect.

Citations

Jul 20, 2002·Chemical & Pharmaceutical Bulletin·Keiko HojoKoichi Kawasaki
Jul 6, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanori Mayumi
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·R BalunaE S Vitetta
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Jun 19, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R CrombieJ Laurence
May 19, 2006·Preparative Biochemistry & Biotechnology·Rui-Zhen HouXue-Zhong Zhang
Aug 15, 1998·Biochemical and Biophysical Research Communications·M MaedaT Mayumi
Feb 5, 2003·Advanced Drug Delivery Reviews·Richard B GreenwaldCharles D Conover

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