Amino acids that centrally influence blood pressure and regional blood flow in conscious rats.

Journal of Amino Acids
Yumi Takemoto

Abstract

Functional roles of amino acids have increasingly become the focus of research. This paper summarizes amino acids that influence cardiovascular system via the brain of conscious rats. This paper firstly describes why amino acids are selected and outlines how the brain regulates blood pressure and regional blood flow. This section includes a concise history of amino acid neurotransmitters in cardiovascular research and summarizes brain areas where chemical stimulations produce blood pressure changes mainly in anesthetized animals. This is followed by comments about findings regarding several newly examined amino acids with intracisternal stimulation in conscious rats that produce changes in blood pressure. The same pressor or depressor response to central amino acid stimulations can be produced by distinct mechanisms at central and peripheral levels, which will be briefly explained. Thereafter, cardiovascular actions of some of amino acids at the mechanism level will be discussed based upon findings of pharmacological and regional blood flow measurements. Several examined amino acids in addition to the established neurotransmitter amino acids appear to differentially activate brain structures to produce changes in blood pressure...Continue Reading

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Citations

Mar 3, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Juan Antonio Pineda-JuárezAlberto Ronquillo-Martínez
Nov 20, 2012·Angewandte Chemie·Jayanta ChatterjeeHorst Kessler
Jun 18, 2020·Nutrients·Chien-Ning Hsu, You-Lin Tain
May 15, 2021·Journal of Nutrition and Metabolism·Demetra J Mills
Aug 19, 2021·Nature Communications·Taiyun KimJean Yee Hwa Yang

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