PMID: 6167438Jun 1, 1981Paper

Amino-terminal sequence of chicken preproalbumin

European Journal of Biochemistry
S J CompereR T MacGillivray

Abstract

Poly(A)-containing RNA was isolated from chicken liver and translated in a reticulocyte lysate protein-synthesizing system in the presence of radiolabeled amino acids. Chicken albumin was isolated from the translation products by immunoprecipitation and subjected to automated Edman radiosequencing. Comparison with the sequence of proalbumin showed that the translocation product (preproalbumin) contains an NH2-terminal extension of 18 amino acid residues. The NH2-terminal sequence of chicken preproalbumin was as follows: Met-18-Lys-Asn-Val-15-Thr-Leu-Ile-Ser-Phe-10-Ile-Phe-Leu-Phe-Ser-5-Ser-Ala-Thr- Ser-1-Arg1, where Arg1 represents the NH2-terminal residue of proalbumin. This NH2-terminal extension is very rich in hydrophobic amino acid residues and is similar to the signal sequences found in other secreted proteins. The signal sequence of chicken preproalbumin shows considerable homology with the signal sequences of rat and bovine preproalbumins, but little homology with the signal sequences of other chicken preproteins.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J F HabenerJ T Potts
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R D PalmiterK A Walsh
Aug 1, 1979·European Journal of Biochemistry·R T McGillivrayE W Davie
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Oct 10, 1977·Biochemical and Biophysical Research Communications·A M Rosen, D M Geller
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Sep 27, 1972·Nature: New Biology·C MilsteinM B Mathews
Nov 21, 1972·Biochemistry·M A HermodsonK A Walsh
Jan 1, 1980·Annals of the New York Academy of Sciences·R D PalmiterI Boime

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Citations

Apr 10, 1984·Biochemistry·R T MacGillivray, E W Davie

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