PMID: 6028026Jul 28, 1967Paper

Aminoaciduria resulting from cycloleucine administration in man

Science
R R Brown

Abstract

Cycloleucine (1-aminocyclopentanecarboxylic acid) administration in cancer patients resulted in a reversible marked aminoaciduria consisting predominantly of cystine, ornithine, lysine, and arginine, with only minor elevations of other amino acids. Plasma levels of amino acids were essentially unchanged except for slight decreases in ornithine and lysine. This aminoaciduria is most likely due to a blockage by the drug of the renal tubular reabsorption of cystine, ornithine, lysine, and arginine, resulting in an aminoaciduria of the type seen in cystinuria.

References

Dec 9, 1966·Science·L E Rosenberg
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Nov 1, 1960·Analytical Biochemistry·K A PIEZ, L MORRIS
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Citations

Jan 1, 1993·Journal of Clinical Pharmacology·J D KaunitzG T Nagami
Jun 1, 1984·Pflügers Archiv : European journal of physiology·J A Schafer, M L Watkins
Dec 15, 1968·Experientia·M E Rosenthale, M I Gluckman
Jan 5, 1981·Life Sciences·A G Craan
Apr 1, 1979·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·P ParvyP Kamoun
Mar 1, 1968·Biochimica Et Biophysica Acta·H N Christensen, A M Cullen
Aug 1, 1969·Analytical Biochemistry·F W JanssenH W Ruelius
Nov 1, 1978·Metabolism: Clinical and Experimental·A G Craan, M Bergeron
Jul 1, 1976·Cancer·C WisemanK B McCredie
Jul 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LemonnierP Levillain

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